BACKGROUND AND OBJECTIVES: Coagulase-negative Staphylococcus species is the most common cause of peritoneal dialysis-related peritonitis; however, the optimal treatment strategy of coagulase-negative Staphylococcus species peritonitis remains controversial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All of the coagulase-negative Staphylococcus species peritonitis in a dialysis unit from 1995 to 2006 were reviewed. During this period, there were 2037 episodes of peritonitis recorded; 232 episodes (11.4%) in 155 patients were caused by coagulase-negative Staphylococcus species. RESULTS: The overall primary response rate was 95.3%; the complete cure rate was 71.1%. Patients with a history of recent hospitalization or recent antibiotic therapy had a higher risk for developing methicillin-resistant strains. Episodes that were treated initially with cefazolin or vancomycin had similar primary response rate and complete cure rate. There were 33 (14.2%) episodes of relapse and 29 (12.5%) episodes of repeat peritonitis; 12 (60.6%) of the repeat episodes developed within 3 mo after completion of antibiotics. Relapse or repeat episodes had a significantly lower complete cure rate than the other episodes. For relapse or repeat episodes, treatment with effective antibiotics for 3 wk was associated with a significantly higher complete cure rate than the conventional 2-wk treatment. CONCLUSIONS: Coagulase-negative Staphylococcus species peritonitis remains a common complication of peritoneal dialysis. Methicillin resistance is common, but the treatment outcome remains favorable when cefazolin is used as the first-line antibiotic. A 3-wk course of antibiotic can probably achieve a higher cure rate in relapse or repeat episodes.
BACKGROUND AND OBJECTIVES: Coagulase-negative Staphylococcus species is the most common cause of peritoneal dialysis-related peritonitis; however, the optimal treatment strategy of coagulase-negative Staphylococcus species peritonitis remains controversial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: All of the coagulase-negative Staphylococcus species peritonitis in a dialysis unit from 1995 to 2006 were reviewed. During this period, there were 2037 episodes of peritonitis recorded; 232 episodes (11.4%) in 155 patients were caused by coagulase-negative Staphylococcus species. RESULTS: The overall primary response rate was 95.3%; the complete cure rate was 71.1%. Patients with a history of recent hospitalization or recent antibiotic therapy had a higher risk for developing methicillin-resistant strains. Episodes that were treated initially with cefazolin or vancomycin had similar primary response rate and complete cure rate. There were 33 (14.2%) episodes of relapse and 29 (12.5%) episodes of repeat peritonitis; 12 (60.6%) of the repeat episodes developed within 3 mo after completion of antibiotics. Relapse or repeat episodes had a significantly lower complete cure rate than the other episodes. For relapse or repeat episodes, treatment with effective antibiotics for 3 wk was associated with a significantly higher complete cure rate than the conventional 2-wk treatment. CONCLUSIONS: Coagulase-negative Staphylococcus species peritonitis remains a common complication of peritoneal dialysis. Methicillin resistance is common, but the treatment outcome remains favorable when cefazolin is used as the first-line antibiotic. A 3-wk course of antibiotic can probably achieve a higher cure rate in relapse or repeat episodes.
Authors: P K Li; M Ip; M C Law; C C Szeto; C B Leung; T Y Wong; K K Ho; A Y Wang; S F Lui; A W Yu; D J Lyon; A F Cheng; K N Lai Journal: Perit Dial Int Date: 2000 Mar-Apr Impact factor: 1.756
Authors: Elaine Marques de Mattos; Lenise Arneiro Teixeira; Vanda Maria Morgado Alves; Cleide Aparecida Ferreira Rezenda e Resende; Marcus Vinícius da Silva Coimbra; Maria Cícera da Silva-Carvalho; Bernadete Teixeira Ferreira-Carvalho; Agnes Marie Sá Figueiredo Journal: Diagn Microbiol Infect Dis Date: 2003-01 Impact factor: 2.803
Authors: Philip Kam-Tao Li; Man Ching Law; Kai Ming Chow; Wing Ki Chan; Cheuk Chun Szeto; Yuk Lun Cheng; Teresa Yuk-Hwa Wong; Chi Bon Leung; Angela Yee-Moon Wang; Siu Fai Lui; Alex Wai-Yin Yu Journal: Am J Kidney Dis Date: 2002-08 Impact factor: 8.860
Authors: Luiz Gustavo Oliveira; Juliana Luengo; Jacqueline C T Caramori; Augusto C Montelli; Maria de Lourdes R S Cunha; Pasqual Barretti Journal: Int Urol Nephrol Date: 2012-10 Impact factor: 2.370