Literature DB >> 18032111

The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Xin-Yun Lu1.   

Abstract

The adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

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Year:  2007        PMID： 18032111      PMCID： PMC2677994          DOI： 10.1016/j.coph.2007.10.010

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  59 in total

1.  Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress.

Authors:  M L Heiman; R S Ahima; L S Craft; B Schoner; T W Stephens; J S Flier
Journal:  Endocrinology       Date:  1997-09       Impact factor: 4.736

2.  Sexual diergism of baseline plasma leptin and leptin suppression by arginine vasopressin in major depressives and matched controls.

Authors:  Robert T Rubin; Michael E Rhodes; R Kenneth Czambel
Journal:  Psychiatry Res       Date:  2002-12-30       Impact factor: 3.222

3.  Robust leptin secretory responses to dexamethasone in obese subjects.

Authors:  S Dagogo-Jack; G Selke; A K Melson; J W Newcomer
Journal:  J Clin Endocrinol Metab       Date:  1997-10       Impact factor: 5.958

4.  Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly.

Authors:  S R Bornstein; K Uhlmann; A Haidan; M Ehrhart-Bornstein; W A Scherbaum
Journal:  Diabetes       Date:  1997-07       Impact factor: 9.461

Review 5.  Pharmacology of antidepressants.

Authors:  A Frazer
Journal:  J Clin Psychopharmacol       Date:  1997-04       Impact factor: 3.153

6.  Plasma leptin in depressed patients and healthy controls.

Authors:  M Deuschle; W F Blum; P Englaro; U Schweiger; B Weber; C D Pflaum; I Heuser
Journal:  Horm Metab Res       Date:  1996-12       Impact factor: 2.936

7.  Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects.

Authors:  J P Miell; P Englaro; W F Blum
Journal:  Horm Metab Res       Date:  1996-12       Impact factor: 2.936

8.  Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

Authors:  J Licinio; C Mantzoros; A B Negrão; G Cizza; M L Wong; P B Bongiorno; G P Chrousos; B Karp; C Allen; J S Flier; P W Gold
Journal:  Nat Med       Date:  1997-05       Impact factor: 53.440

Review 9.  Obesity-depression associations in the population.

Authors:  Myles S Faith; Patty E Matz; Marie A Jorge
Journal:  J Psychosom Res       Date:  2002-10       Impact factor: 3.006

10.  Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice.

Authors:  S J Vannucci; E M Gibbs; I A Simpson
Journal:  Am J Physiol       Date:  1997-02
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  96 in total

1.  Leptin, abdominal obesity, and onset of depression in older men and women.

Authors:  Yuri Milaneschi; Eleanor M Simonsick; Nicole Vogelzangs; Elsa S Strotmeyer; Kristine Yaffe; Tamara B Harris; Magdalena I Tolea; Luigi Ferrucci; Brenda W J H Penninx
Journal:  J Clin Psychiatry       Date:  2012-05-29       Impact factor: 4.384

2.  Psychopathology in underweight and weight-recovered females with anorexia nervosa.

Authors:  N Schneider; H Salbach-Andrae; J V Merle; J Hein; E Pfeiffer; U Lehmkuhl; S Ehrlich
Journal:  Eat Weight Disord       Date:  2009-12       Impact factor: 4.652

3.  Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways.

Authors:  Diana A Chirinos; Indira Gurubhagavatula; Preston Broderick; Julio A Chirinos; Karen Teff; Thomas Wadden; Greg Maislin; Hassam Saif; Jesse Chittams; Caitlin Cassidy; Alexandra L Hanlon; Allan I Pack
Journal:  J Behav Med       Date:  2017-06-21

Review 4.  Functional biomarkers of depression: diagnosis, treatment, and pathophysiology.

Authors:  Heath D Schmidt; Richard C Shelton; Ronald S Duman
Journal:  Neuropsychopharmacology       Date:  2011-08-03       Impact factor: 7.853

5.  Depression and the risk of psoriasis in US women.

Authors:  P L Dominguez; J Han; T Li; A Ascherio; A A Qureshi
Journal:  J Eur Acad Dermatol Venereol       Date:  2012-10-03       Impact factor: 6.166

Review 6.  Effects of Curcumin on Depression and Anxiety: A Narrative Review of the Recent Clinical Data.

Authors:  Mohammad Amin Khodadadegan; Shakiba Azami; Paul C Guest; Tannaz Jamialahmadi; Amirhossein Sahebkar
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

7.  Amylin-induced downregulation of hippocampal neurogenesis is attenuated by leptin in a STAT3/AMPK/ERK-dependent manner in mice.

Authors:  H-S Moon; F Dincer; C S Mantzoros
Journal:  Diabetologia       Date:  2012-12-09       Impact factor: 10.122

8.  Gender differences in the association between body mass index and psychopathology.

Authors:  Rani A Desai; Melinda Manley; Mayur M Desai; Marc N Potenza
Journal:  CNS Spectr       Date:  2009-07       Impact factor: 3.790

9.  Prepregnancy body mass index, gestational weight gain, and the likelihood of major depressive disorder during pregnancy.

Authors:  Lisa M Bodnar; Katherine L Wisner; Eydie Moses-Kolko; Dorothy K Y Sit; Barbara H Hanusa
Journal:  J Clin Psychiatry       Date:  2009-07-14       Impact factor: 4.384

10.  An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: possible implications for cancer research.

Authors:  Faina Linkov; Lora E Burke; Marina Komaroff; Robert P Edwards; Anna Lokshin; Mindi A Styn; Eugene Tseytlin; Kyle E Freese; Dana H Bovbjerg
Journal:  Gynecol Oncol       Date:  2014-01-22       Impact factor: 5.482
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