OBJECTIVE: We investigated electroencephalographic (EEG) correlates of moderate intermittent explosive disorder (mIED), which is characterized by uncontrollable, impulsive attacks that either manifest in aggressive outbursts of temper, or in implosive, auto-aggressive behaviour. METHODS: In two Experiments, EEG data were recorded during rest conditions, and while subjects were presented with auditory and visual stimuli. Additionally, scores of the I7 impulsivity scale (designed to capture acting on impulse) were obtained. RESULTS: In Experiment 1, individuals with mIED showed a stronger increase in the power of oscillatory activity in the beta band, along with a stronger power decrease in the theta band in response to both visual and auditory stimuli. Based on discriminant function analysis, a model of discriminant functions was derived that clearly separated the mIED group from the control group. In Experiment 2, subjects were categorized into either of two groups (supposedly without mIED, with mIED) based on this model of discriminant functions. Results showed that I7 impulsivity scores clearly differed between groups. CONCLUSIONS: The present data show a relation between oscillatory brain activity and mIED. They indicate that this brain activity is related to the impulsivity facet of impulsive action, and suggest that mIED can be assessed based on the analysis of electrophysiological data. SIGNIFICANCE: To our knowledge, this is the first study on EEG correlates of (m)IED. Results open up new perspectives for future investigations on disorders characterized by substantial impulsivity.
OBJECTIVE: We investigated electroencephalographic (EEG) correlates of moderate intermittent explosive disorder (mIED), which is characterized by uncontrollable, impulsive attacks that either manifest in aggressive outbursts of temper, or in implosive, auto-aggressive behaviour. METHODS: In two Experiments, EEG data were recorded during rest conditions, and while subjects were presented with auditory and visual stimuli. Additionally, scores of the I7 impulsivity scale (designed to capture acting on impulse) were obtained. RESULTS: In Experiment 1, individuals with mIED showed a stronger increase in the power of oscillatory activity in the beta band, along with a stronger power decrease in the theta band in response to both visual and auditory stimuli. Based on discriminant function analysis, a model of discriminant functions was derived that clearly separated the mIED group from the control group. In Experiment 2, subjects were categorized into either of two groups (supposedly without mIED, with mIED) based on this model of discriminant functions. Results showed that I7 impulsivity scores clearly differed between groups. CONCLUSIONS: The present data show a relation between oscillatory brain activity and mIED. They indicate that this brain activity is related to the impulsivity facet of impulsive action, and suggest that mIED can be assessed based on the analysis of electrophysiological data. SIGNIFICANCE: To our knowledge, this is the first study on EEG correlates of (m)IED. Results open up new perspectives for future investigations on disorders characterized by substantial impulsivity.
Authors: Daniel Pantoja Estumano; Luan Oliveira Ferreira; Paulo Augusto Lima Bezerra; Maria Clara Pinheiro da Silva; Giovanna Coutinho Jardim; George Francisco Souza Santos; Kayo Silva Gustavo; Bruna Gerrits Mattos; Jorge Amando Batista Ramos; Vanessa Jóia de Mello; Edmar Tavares da Costa; Dielly Catrina Favacho Lopes; Moisés Hamoy Journal: Front Endocrinol (Lausanne) Date: 2019-09-24 Impact factor: 5.555
Authors: Steffen Barra; Daniel Turner; Marcus Müller; Priscilla Gregorio Hertz; Petra Retz-Junginger; Oliver Tüscher; Michael Huss; Wolfgang Retz Journal: Eur Arch Psychiatry Clin Neurosci Date: 2020-08-11 Impact factor: 5.270