| Literature DB >> 18032039 |
Saeed Emami1, Alireza Foroumadi, Mehraban Falahati, Ensieh Lotfali, Saeed Rajabalian, Soltan-Ahmed Ebrahimi, Shirin Farahyar, Abbas Shafiee.
Abstract
2-Hydroxyphenacyl azole and 2-hydroxyphenacyl azolium compounds have been described as a new class of azole antifungals. Most target compounds showed significant in vitro antifungal activities against tested fungi (Candida albicans, Saccharomyces cerevisiae, Aspergillus niger, and Microsporum gypseum) with low MICs values included in the range of 0.25-32 microg/mL comparable to reference drug fluconazole. The most active compounds were also assessed for their cytotoxicity using MTT colorimetric assay on normal mouse fibroblast (NIH/3T3) cells. The results of antifungal activity and toxicity tests indicated that these compounds display antifungal activity at non-cytotoxic concentrations.Entities:
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Year: 2007 PMID： 18032039 DOI： 10.1016/j.bmcl.2007.10.111
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823