| Literature DB >> 18031691 |
Abstract
Specificity of T cell receptors (TCRs) to major histocompatibility complex (MHC) might be intrinsic or imposed by thymic selection. Van Laethem et al. (2007) propose that the sequestration of the kinase Lck by coreceptors prevents the selection of non-MHC-reactive TCRs.Entities:
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Year: 2007 PMID： 18031691 DOI： 10.1016/j.immuni.2007.11.002
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745