OBJECTIVE: The success of an amylin analogue in weight loss trials has generated interest in amylin as a physiological satiety signal. Little is known about how plasma amylin responds to macronutrients. This study examined the effects of a high-carbohydrate meal (CHO), a high-fat meal (FAT) or a continued fast (FAST) on amylin concentrations and correlations among other satiety hormones and measures of appetite. DESIGN/PATIENTS: In a randomized, crossover design, 10 healthy males consumed a meal high in carbohydrate or fat or continued fasted. MEASUREMENTS: Blood samples and subjective hunger scores were obtained at baseline and 30, 90 and 210 min postprandial. RESULTS: After CHO, amylin, insulin and C-peptide were greater and des-acyl ghrelin lower compared to FAT (P < 0.001). Area under the curve (AUC) was greater for amylin and insulin and lower for des-acyl ghrelin following CHO. Subjective satiety and fullness were higher for CHO and FAT than FAST at 30 and 90 min but only for CHO at 210 min (P < 0.01). Hunger and desire to eat were lower for CHO and FAT than FAST at 30 and 90 min but only for CHO at 210 min (P < 0.005). Amylin was negatively correlated to hunger, desire to eat, and nausea and positively related to satiety and insulin. Des-acyl ghrelin was negatively associated with C-peptide, insulin and GLP-1 and satiety. CONCLUSIONS: CHO enhances amylin and suppresses des-acyl ghrelin to a greater extent than FAT in healthy men. The mechanisms responsible for these changes and their implications in the physiology of satiety remain to be elucidated.
RCT Entities:
OBJECTIVE: The success of an amylin analogue in weight loss trials has generated interest in amylin as a physiological satiety signal. Little is known about how plasma amylin responds to macronutrients. This study examined the effects of a high-carbohydrate meal (CHO), a high-fat meal (FAT) or a continued fast (FAST) on amylin concentrations and correlations among other satiety hormones and measures of appetite. DESIGN/PATIENTS: In a randomized, crossover design, 10 healthy males consumed a meal high in carbohydrate or fat or continued fasted. MEASUREMENTS: Blood samples and subjective hunger scores were obtained at baseline and 30, 90 and 210 min postprandial. RESULTS: After CHO, amylin, insulin and C-peptide were greater and des-acyl ghrelin lower compared to FAT (P < 0.001). Area under the curve (AUC) was greater for amylin and insulin and lower for des-acyl ghrelin following CHO. Subjective satiety and fullness were higher for CHO and FAT than FAST at 30 and 90 min but only for CHO at 210 min (P < 0.01). Hunger and desire to eat were lower for CHO and FAT than FAST at 30 and 90 min but only for CHO at 210 min (P < 0.005). Amylin was negatively correlated to hunger, desire to eat, and nausea and positively related to satiety and insulin. Des-acyl ghrelin was negatively associated with C-peptide, insulin and GLP-1 and satiety. CONCLUSIONS:CHO enhances amylin and suppresses des-acyl ghrelin to a greater extent than FAT in healthy men. The mechanisms responsible for these changes and their implications in the physiology of satiety remain to be elucidated.
Authors: Elizabeth G Mietlicki-Baase; Lauren E McGrath; Kieran Koch-Laskowski; Joanna Krawczyk; David J Reiner; Tram Pham; Chan Tran N Nguyen; Christopher A Turner; Diana R Olivos; Mathieu E Wimmer; Heath D Schmidt; Matthew R Hayes Journal: Neuropharmacology Date: 2017-05-25 Impact factor: 5.250
Authors: Angela Kong; Marian L Neuhouser; Liren Xiao; Cornelia M Ulrich; Anne McTiernan; Karen E Foster-Schubert Journal: Nutr Res Date: 2009-11 Impact factor: 3.315
Authors: Ingunn Narverud; Mari C W Myhrstad; Karl-Heinz Herzig; Toni Karhu; Tuva B Dahl; Bente Halvorsen; Stine M Ulven; Kirsten B Holven Journal: Front Nutr Date: 2016-08-31