OBJECTIVES: Inflammation may contribute to progression of knee osteoarthritis (OA). Therefore, we investigated whether innate differences in the inflammatory response regarding cytokine production were associated with radiological progression of knee OA. METHODS: Symptomatic patients with knee OA (n = 89) were included. Standardised posteroanterior knee radiographs were obtained at baseline and after 24 months. Medial and lateral tibiofemoral joint space narrowing (JSN) was graded with the Altman atlas. Radiological progression was defined as an increase of at least one score in JSN total scores. Whole blood samples were stimulated with lipopolysaccharide (LPS) (10 ng/ml). Relative risks (RR) with 95% CIs of OA progression in relation to quartiles of innate ex vivo production of interleukin (IL)1beta, tumour necrosis factor (TNF)alpha, IL1 receptor antagonist (Ra) and IL10 were calculated. RESULTS: Progression of JSN was present in 29 (33.7%) of 86 followed patients after 2 years. Patients in the highest quartile of TNFalpha production had a sixfold increased risk of JSN progression (age, sex and body mass index adjusted RR 6.1, 95% CI 1.4 to 9.8) and patients in the highest quartile of IL10 production had a fourfold increased risk of JSN progression (age, sex and body mass index adjusted RR 4.3, 95% CI 1.7 to 6.2), both in comparison with those patients in the lowest quartile. No significant associations were found between variations in IL1beta and IL1Ra production and JSN progression. CONCLUSION: The innate capacity to produce TNFalpha and IL10 upon LPS stimulation is associated with radiological progression of knee OA, even over a relatively short follow-up period of 2 years.
OBJECTIVES: Inflammation may contribute to progression of knee osteoarthritis (OA). Therefore, we investigated whether innate differences in the inflammatory response regarding cytokine production were associated with radiological progression of knee OA. METHODS: Symptomatic patients with knee OA (n = 89) were included. Standardised posteroanterior knee radiographs were obtained at baseline and after 24 months. Medial and lateral tibiofemoral joint space narrowing (JSN) was graded with the Altman atlas. Radiological progression was defined as an increase of at least one score in JSN total scores. Whole blood samples were stimulated with lipopolysaccharide (LPS) (10 ng/ml). Relative risks (RR) with 95% CIs of OA progression in relation to quartiles of innate ex vivo production of interleukin (IL)1beta, tumour necrosis factor (TNF)alpha, IL1 receptor antagonist (Ra) and IL10 were calculated. RESULTS: Progression of JSN was present in 29 (33.7%) of 86 followed patients after 2 years. Patients in the highest quartile of TNFalpha production had a sixfold increased risk of JSN progression (age, sex and body mass index adjusted RR 6.1, 95% CI 1.4 to 9.8) and patients in the highest quartile of IL10 production had a fourfold increased risk of JSN progression (age, sex and body mass index adjusted RR 4.3, 95% CI 1.7 to 6.2), both in comparison with those patients in the lowest quartile. No significant associations were found between variations in IL1beta and IL1Ra production and JSN progression. CONCLUSION: The innate capacity to produce TNFalpha and IL10 upon LPS stimulation is associated with radiological progression of knee OA, even over a relatively short follow-up period of 2 years.
Authors: Karel G M Beenakker; Rudi G J Westendorp; Anton J M de Craen; Sijia Chen; Yotam Raz; Bart E P B Ballieux; Rob G H H Nelissen; Alexander F L Later; Tom W Huizinga; Pieternella E Slagboom; Dorret I Boomsma; Andrea B Maier Journal: J Innate Immun Date: 2019-06-21 Impact factor: 7.349
Authors: B Moradi; N Rosshirt; E Tripel; J Kirsch; A Barié; F Zeifang; T Gotterbarm; S Hagmann Journal: Clin Exp Immunol Date: 2015-04 Impact factor: 4.330
Authors: Ana M Valdes; John Loughlin; Kirsten M Timms; Joyce J B van Meurs; Lorraine Southam; Scott G Wilson; Sally Doherty; Rik J Lories; Frank P Luyten; Alexander Gutin; Victor Abkevich; Dongliang Ge; Albert Hofman; André G Uitterlinden; Deborah J Hart; Feng Zhang; Guangju Zhai; Rainer J Egli; Michael Doherty; Jerry Lanchbury; Tim D Spector Journal: Am J Hum Genet Date: 2008-05-08 Impact factor: 11.025
Authors: Mark M T J Broekman; Hennie M J Roelofs; Frank Hoentjen; Renske Wiegertjes; Nicole Stoel; Leo A Joosten; Dirk J de Jong; Geert J A Wanten Journal: PLoS One Date: 2015-07-24 Impact factor: 3.240