OBJECTIVES: To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM). DESIGN AND METHODS: MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis. RESULTS: Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls. CONCLUSIONS: Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM.
OBJECTIVES: To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM). DESIGN AND METHODS: MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis. RESULTS: Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls. CONCLUSIONS: Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM.
Authors: Ana Rubia C Beber; Evelise R Polina; Andréia Biolo; Bruna L Santos; Daiane C Gomes; Vanessa L La Porta; Virgílio Olsen; Nadine Clausell; Luis E Rohde; Kátia G Santos Journal: PLoS One Date: 2016-08-23 Impact factor: 3.240
Authors: Evangelia E Tsironi; Maria Pefkianaki; Aspasia Tsezou; Maria G Kotoula; Efthimios Dardiotis; Pavlina Almpanidou; Afroditi A Papathanasiou; Paraskevi Rodopoulou; Dimitrios Z Chatzoulis; Georgios M Hadjigeorgiou Journal: Mol Vis Date: 2009-12-25 Impact factor: 2.367