Literature DB >> 18028483

Serum lactate dehydrogenase activity as a biomarker in children with sickle cell disease.

Sandra O'Driscoll1, Susan E Height, Moira C Dick, David C Rees.   

Abstract

Serum lactate dehydrogenase (LDH) levels were studied in children with HbSS and HbSC in a single institution, and their relationship to cerebral vasculopathy as assessed by transcranial Doppler scanning (TCD). All children with HbSS (n = 97) and HbSC (n = 18) who underwent a TCD scan in 2006 were studied. LDH levels were higher in HbSS patients than HbSC (581 IU/l vs. 305 IU/l, P < 0.001). In children with HbSS, LDH correlated significantly with haemoglobin, reticulocytes, aspartate transaminase and creatinine. LDH also correlated positively and significantly with TCD measurements in the middle and anterior cerebral artery circulations in the children with HbSS.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18028483     DOI： 10.1111/j.1365-2141.2007.06894.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  14 in total

Review 1.  Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.

Authors:  Eboni I Lance; James F Casella; Allen D Everett; Emily Barron-Casella
Journal:  Proteomics Clin Appl       Date:  2014-11-06       Impact factor: 3.494

2.  Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia.

Authors:  Charles T Quinn; Eric P Smith; Shahriar Arbabi; Paramjit K Khera; Christopher J Lindsell; Omar Niss; Clinton H Joiner; Robert S Franco; Robert M Cohen
Journal:  Am J Hematol       Date:  2016-11-08       Impact factor: 10.047

Review 3.  Improving outcomes in children with sickle cell disease: treatment considerations and strategies.

Authors:  Ali Amid; Isaac Odame
Journal:  Paediatr Drugs       Date:  2014-08       Impact factor: 3.022

4.  Extracranial internal carotid arterial disease in children with sickle cell anemia.

Authors:  Colin R Deane; David Goss; Jack Bartram; Keith R E Pohl; Susan E Height; Naomi Sibtain; Jozef Jarosz; Swee Lay Thein; David C Rees
Journal:  Haematologica       Date:  2010-03-10       Impact factor: 9.941

5.  Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease.

Authors:  Erdem Kucukal; Anton Ilich; Nigel S Key; Jane A Little; Umut A Gurkan
Journal:  Am J Hematol       Date:  2018-06-15       Impact factor: 10.047

6.  Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises.

Authors:  Suba Krishnan; Yamaja Setty; Suhita G Betal; Vaidyula Vijender; Koneti Rao; Carlton Dampier; Marie Stuart
Journal:  Br J Haematol       Date:  2009-12-08       Impact factor: 6.998

7.  Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.

Authors:  Magda O Seixas; Larissa C Rocha; Mauricio B Carvalho; Joelma F Menezes; Isa M Lyra; Valma M L Nascimento; Ricardo D Couto; Ájax M Atta; Mitermayer G Reis; Marilda S Goncalves
Journal:  Lipids Health Dis       Date:  2010-08-27       Impact factor: 3.876

8.  Monitoring retinal pathology and cerebral injury in sickle cell disease using spectral-domain optical coherence tomography in pediatric patients.

Authors:  Jing Jin; Vinay Kandula; Robin E Miller
Journal:  Pediatr Blood Cancer       Date:  2021-03-31       Impact factor: 3.838

9.  Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain.

Authors:  James G Taylor; Vikki G Nolan; Laurel Mendelsohn; Gregory J Kato; Mark T Gladwin; Martin H Steinberg
Journal:  PLoS One       Date:  2008-05-07       Impact factor: 3.240

10.  Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.

Authors:  Yuncheng Man; Erdem Kucukal; Ran An; Allison Bode; Jane A Little; Umut A Gurkan
Journal:  Microcirculation       Date:  2021-01-09       Impact factor: 2.628
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.