| Literature DB >> 18027959 |
Nadège Boudet1, Jennifer R Lachs, Paul Knochel.
Abstract
A wide range of polyfunctionalized quinolines was prepared via chemo- and regioselective magnesiation reactions using appropriate Mg reagents, such as i-PrMgCl.LiCl, MesMgBr.LiCl, Mes2Mg.2LiBr, TMPMgCl.LiCl, and TMP2Mg.2LiCl. An application to the total synthesis of the biologically active compound talnetant was performed (six steps, 28%).Entities:
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Year: 2007 PMID： 18027959 DOI： 10.1021/ol702494k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005