| Literature DB >> 18027906 |
Malcolm S Buchanan1, Anthony R Carroll, Rama Addepalli, Vicky M Avery, John N A Hooper, Ronald J Quinn.
Abstract
As part of our studies to discover P2X 7 receptor antagonists, the sponge Callyspongia sp. was investigated. A new tripyridine alkaloid niphatoxin C ( 1) was isolated and had P2X 7 receptor antagonism; however, cytotoxicity of THP-1 cells was the predominant biological effect at higher concentrations. Its structure was determined by 1- and 2-D NMR spectroscopy.Entities:
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Year: 2007 PMID： 18027906 DOI： 10.1021/np070366q
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050