Literature DB >> 18027182

Preparation and in vitro evaluation of bFGF-loaded chitosan nanoparticles.

Meltem Cetin1, Yesim Aktas, Imran Vural, Yilmaz Capan, Lale A Dogan, Memed Duman, Turgay Dalkara.   

Abstract

The objective of our study was to prepare and characterize basic fibroblast growth factor (bFGF)-loaded nanoparticles. Protein-loaded chitosan nanoparticles were obtained by ionotropic gelation process based on the interaction between chitosan and tripolyphosphate (TPP). The protein-loading capacity and encapsulation efficiency were 0.021% and 27.388%, respectively. The bFGF-loaded nanoparticles have a mean diameter of 424 nm, a narrow size distribution, spherical shape and positive surface charges. In vitro release showed that the extent of release was 68% at 24 hr. The protein integrity was investigated by SDS-PAGE analysis that confirmed protein integrity was not affected by the encapsulation procedure and release conditions.

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Year:  2007        PMID： 18027182     DOI： 10.1080/10717540701606483

Source DB:  PubMed          Journal:  Drug Deliv        ISSN： 1071-7544            Impact factor:   6.419


  8 in total

Review 1.  Methods for the preparation and manufacture of polymeric nanoparticles.

Authors:  Christine Vauthier; Kawthar Bouchemal
Journal:  Pharm Res       Date:  2008-12-24       Impact factor: 4.200

Review 2.  Nanoparticulate systems for growth factor delivery.

Authors:  Sufeng Zhang; Hasan Uludağ
Journal:  Pharm Res       Date:  2009-05-05       Impact factor: 4.200

3.  A fibrin gel loaded with chitosan nanoparticles for local delivery of rhEGF: preparation and in vitro release studies.

Authors:  Wenjun Zhou; Min Zhao; Yuan Zhao; Yan Mou
Journal:  J Mater Sci Mater Med       Date:  2011-03-29       Impact factor: 3.896

4.  Preparation of NGF encapsulated chitosan nanoparticles and its evaluation on neuronal differentiation potentiality of canine mesenchymal stem cells.

Authors:  Bhabesh Mili; Kinsuk Das; Ajay Kumar; A C Saxena; Praveen Singh; Srikanta Ghosh; Sadhan Bag
Journal:  J Mater Sci Mater Med       Date:  2017-12-04       Impact factor: 3.896

5.  Formulation and in vitro characterization of Eudragit® L100 and Eudragit® L100-PLGA nanoparticles containing diclofenac sodium.

Authors:  Meltem Cetin; Alptug Atila; Yucel Kadioglu
Journal:  AAPS PharmSciTech       Date:  2010-08-10       Impact factor: 3.246

6.  Dendrimer-based tumor cell targeting of fibroblast growth factor-1.

Authors:  Thommey P Thomas; Rameshwer Shukla; Alina Kotlyar; Jola Kukowska-Latallo; James R Baker
Journal:  Bioorg Med Chem Lett       Date:  2009-12-03       Impact factor: 2.823

7.  Superhydrophobic Surface for Enhancing the Bioavailability of Salbutamol Sulfate from Cross-Linked Microspheres: Formulation, Characterization, and in vivo Evaluation.

Authors:  Dalia Gaber; Siham Abdoun; Ameerah Alfuraihy; Bushra Altasan; Amal Alsubaiyel
Journal:  Drug Des Devel Ther       Date:  2021-07-02       Impact factor: 4.162

Review 8.  Nanochitosan: Commemorating the Metamorphosis of an ExoSkeletal Waste to a Versatile Nutraceutical.

Authors:  Iyyakkannu Sivanesan; Manikandan Muthu; Judy Gopal; Nazim Hasan; Syed Kashif Ali; Juhyun Shin; Jae-Wook Oh
Journal:  Nanomaterials (Basel)       Date:  2021-03-23       Impact factor: 5.076
  8 in total

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