PURPOSE: To assess histopathologic prognostic factors relative to clinical ones in predicting local recurrence and survival after primary conjunctival melanoma (CM). METHODS: 85 patients with CM were identified in Finland between 1967 and 2000, and 70 primary tumors were available for histopathologic study. Time to first recurrence and melanoma-related mortality were analyzed. RESULTS: Absence of epithelioid cells (P=0.033), smaller mean diameter of the ten largest nucleoli (P=0.041) and increasing mitotic count (P=0.042) were associated with shorter time to recurrence. The mean diameter of the ten largest nucleoli, the number of tumor-infiltrating lymphocytes and macrophages, extravascular matrix loops and networks, and microvascular density were unassociated with recurrence. Nonlimbal location (P=0.001), recurrence (P<0.001), and increasing tumor thickness (P=0.007) were associated with mortality. By multivariate Cox regression, a model including recurrence and tumor location fitted best with mortality data. CONCLUSIONS: Histopathological factors are not consistently associated with survival in CM. Tumor location, thickness, and recurrence are predictors of mortality from CM.
PURPOSE: To assess histopathologic prognostic factors relative to clinical ones in predicting local recurrence and survival after primary conjunctival melanoma (CM). METHODS: 85 patients with CM were identified in Finland between 1967 and 2000, and 70 primary tumors were available for histopathologic study. Time to first recurrence and melanoma-related mortality were analyzed. RESULTS: Absence of epithelioid cells (P=0.033), smaller mean diameter of the ten largest nucleoli (P=0.041) and increasing mitotic count (P=0.042) were associated with shorter time to recurrence. The mean diameter of the ten largest nucleoli, the number of tumor-infiltrating lymphocytes and macrophages, extravascular matrix loops and networks, and microvascular density were unassociated with recurrence. Nonlimbal location (P=0.001), recurrence (P<0.001), and increasing tumor thickness (P=0.007) were associated with mortality. By multivariate Cox regression, a model including recurrence and tumor location fitted best with mortality data. CONCLUSIONS: Histopathological factors are not consistently associated with survival in CM. Tumor location, thickness, and recurrence are predictors of mortality from CM.
Authors: Bita Esmaeli; Dianna Roberts; Merrick Ross; Melissa Fellman; Hilda Cruz; Stella K Kim; Victor G Prieto Journal: Trans Am Ophthalmol Soc Date: 2012-12
Authors: P Zimmermann; T Dietrich; F Bock; F K Horn; C Hofmann-Rummelt; F E Kruse; C Cursiefen Journal: Br J Ophthalmol Date: 2009-07-23 Impact factor: 4.638
Authors: Jinfeng Cao; Niels J Brouwer; Kate E Richards; Marina Marinkovic; Sjoerd van Duinen; Daan Hurkmans; Els M E Verdegaal; Ekaterina S Jordanova; Martine J Jager Journal: Oncotarget Date: 2017-05-20