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Literature DB >> 18027108

CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.

Abstract

Regulatory T cells control immune responses to self- and foreign-antigens and play a major role in maintaining the balance between immunity and tolerance. This article reviews recent key developments in the field of CD4+CD25+Foxp3+ regulatory T (TREG) cells. It presents their characteristics and describes their range of activity and mechanisms of action. Some models of diseases triggered by the imbalance between TREG cells and effector pathogenic T cells are described and their potential therapeutic applications in humans are outlined.

Entities: Gene Species

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Year: 2007 PMID： 18027108 DOI： 2007/45/smw-11916

Source DB: PubMed Journal: Swiss Med Wkly ISSN： 0036-7672 Impact factor: 2.193

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Cited

19 in total

1. T regulatory cell function in idiopathic minimal lesion nephrotic syndrome.

Authors: Carlos Araya; Leila Diaz; Clive Wasserfall; Mark Atkinson; Wei Mu; Richard Johnson; Eduardo Garin
Journal: Pediatr Nephrol Date: 2009-06-03 Impact factor: 3.714

2. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection.

Authors: Guangming Gong; Lingyun Shao; Yunqi Wang; Crystal Y Chen; Dan Huang; Shuyu Yao; Ximei Zhan; Helene Sicard; Richard Wang; Zheng W Chen
Journal: Blood Date: 2008-11-03 Impact factor: 22.113

Review 3. Dioxins: diagnostic and prognostic challenges arising from complex mechanisms.

Authors: Noel M Rysavy; Kristina Maaetoft-Udsen; Helen Turner
Journal: J Appl Toxicol Date: 2012-05-19 Impact factor: 3.446

4. Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation.

Authors: Sudhir Kumar; Jiang Wang; Angus W Thomson; Chandrashekhar R Gandhi
Journal: J Leukoc Biol Date: 2016-08-31 Impact factor: 4.962

10. Activation of inflammatory cells and cytokines by peptide epitopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studies.

Authors: Lakshmi A Mundkur; Meenakshi Varma; Hemapriya Shivanandan; Dhanush Krishna; Kiran Kumar; Xinjie Lu; Vijay V Kakkar
Journal: Inflamm Res Date: 2013-02-12 Impact factor: 4.575

CD4+CD25+Foxp3+ regulatory T cells: from basic research to potential therapeutic use.

1. T regulatory cell function in idiopathic minimal lesion nephrotic syndrome.

2. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection.

Review 3. Dioxins: diagnostic and prognostic challenges arising from complex mechanisms.

4. Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation.

Review 5. The podocyte as a target: cyclosporin A in the management of the nephrotic syndrome caused by WT1 mutations.

6. Immunophenotypic profile of leukocytes in hyperandrogenemic female rat an animal model of polycystic ovary syndrome.

7. Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.

Review 8. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system.

9. Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression.

10. Activation of inflammatory cells and cytokines by peptide epitopes in vitro: a simple in-vitro screening assay for prioritizing them for in-vivo studies.