| Literature DB >> 18026843 |
S S Kanwar1, K Lumba, S K Gupta, V M Katoch, P Singh, A K Mishra, S B Kalia.
Abstract
An isonicotinoyldithiocarbazic acid (IN-DtczH) ligand, synthesized from isoniazid, was complexed with transition metals and evaluated for anti-mycobacterial activity as well as toxicity towards human-transformed rhabdomyosarcoma (RD) cells in vitro. Complexes with Ni, Co and Zn showed MIC of 2, 2 and 50 mug/ml against Mycobacterium tuberculosis H(37)Rv, and 10, 100 and 50 mug/ml against a multidrug-resistant strain of M. tuberculosis. They had little cytotoxic effect on the RD cells. In contrast, the Cu complex was highly cytotoxic with a low anti-mycobacterial activity.Entities:
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Year: 2007 PMID： 18026843 DOI： 10.1007/s10529-007-9601-5
Source DB: PubMed Journal: Biotechnol Lett ISSN： 0141-5492 Impact factor: 2.461