Recent innovative studies of memory in temporal lobe epilepsy.

Investigations of patients with temporal lobe epilepsy continue to result in significant advancements in the neuroscience of human memory, as they have for over 50 years. Recent reviews describing the state of the art in the clinical neuropsychology of TLE generally have emphasized (1) lateralization of cognitive deficits and the material-specific model of memory and/or (2) the relationships among pre- and post-surgery performance on standardized measures of anterograde memory, demographic and epilepsy variables and neuroimaging, neuropathology, and neurosurgery data. As information continues to accumulate about the pattern of performance on standard laboratory memory tests and the implications of these data before and after anterior temporal lobectomy for the treatment of TLE, innovative assessment techniques also are increasingly being applied. This review focuses on English language publications that addressed selected novel topics in adult TLE memory research. These topics are: (1) remote memory; (2) accelerated forgetting or long term amnesia; and (3) lateral versus mesial temporal lobe contributions to memory.