| Literature DB >> 18026100 |
Weiqian Mi1, Monika Pawlik, Magdalena Sastre, Sonia S Jung, David S Radvinsky, Andrew M Klein, John Sommer, Stephen D Schmidt, Ralph A Nixon, Paul M Mathews, Efrat Levy.
Abstract
Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice. Cystatin C expression twice that of the endogenous mouse cystatin C was sufficient to substantially diminish amyloid-beta deposition. Thus, cystatin C has a protective role in Alzheimer's disease pathogenesis, and modulation of cystatin C concentrations may have therapeutic implications for the disease.Entities:
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Year: 2007 PMID： 18026100 DOI： 10.1038/ng.2007.29
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330