Literature DB >> 18025747

Wilson's disease presenting as isolated obsessive-compulsive disorder.

B L Kumawat1, C M Sharma, Gautam Tripathi, Tarun Ralot, Shailesh Dixit.   

Abstract

Wilson's disease (WD) is a genetic neurodegenerative disorder; it exhibits wide heterogeneity in symptoms and usually presents with liver disease and/ or neuropsychiatric manifestations. The common neurological manifestations observed are dysarthria, gait disturbance, dystonia, rigidity, tremor, dysphagia and chorea. The frequent psychiatric manifestations reported are personality and mood changes, depression, phobias, cognitive impairment, psychosis, anxiety, compulsive and impulsive behavior. Isolated obsessive-compulsive disorder (OCD) is a rare presentation of WD. Reported herein is a case of a 17-year-old boy with isolated OCD. He presented to the psychiatrist with symptoms of contamination obsessions and washing compulsions, along with compulsion of repeated feet tapping and was treated with adequate doses of fluoxetine for 6 months but did not improve. Later on, he was diagnosed as a case of WD and showed improvement with chelating and behavior therapy. This implies the importance of the occurrence of isolated psychological symptoms in WD.

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Year:  2007        PMID: 18025747

Source DB:  PubMed          Journal:  Indian J Med Sci        ISSN: 0019-5359


  6 in total

Review 1.  Wilson disease.

Authors:  Anna Członkowska; Tomasz Litwin; Petr Dusek; Peter Ferenci; Svetlana Lutsenko; Valentina Medici; Janusz K Rybakowski; Karl Heinz Weiss; Michael L Schilsky
Journal:  Nat Rev Dis Primers       Date:  2018-09-06       Impact factor: 52.329

2.  Complex psychiatric presentation in adolescent onset Wilson's disease.

Authors:  S Woerwag-Mehta; Peter Hindley; Tammy Hedderly; Anil Dhawan
Journal:  BMJ Case Rep       Date:  2011-01-11

3.  A Case to Tear One's Hair Out: Trichotillomania in Wilson's Disease.

Authors:  Tjerk J Lagrand; Laurie McLaughlin; Alexander C Lehn
Journal:  Mov Disord Clin Pract       Date:  2022-07-25

4.  The neuropsychiatry of hyperkinetic movement disorders: insights from neuroimaging into the neural circuit bases of dysfunction.

Authors:  Bradleigh D Hayhow; Islam Hassan; Jeffrey C L Looi; Francesco Gaillard; Dennis Velakoulis; Mark Walterfang
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2013-08-26

Review 5.  Psychiatric manifestations in Wilson's disease: possibilities and difficulties for treatment.

Authors:  Tomasz Litwin; Petr Dusek; Tomasz Szafrański; Karolina Dzieżyc; Anna Członkowska; Janusz K Rybakowski
Journal:  Ther Adv Psychopharmacol       Date:  2018-03-06

Review 6.  Can psychiatric childhood disorders be due to inborn errors of metabolism?

Authors:  A Simons; F Eyskens; I Glazemakers; D van West
Journal:  Eur Child Adolesc Psychiatry       Date:  2016-09-30       Impact factor: 4.785

  6 in total

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