| Literature DB >> 18024410 |
Andrica C H de Vries, Ronald W Stam, Christian P Kratz, Martin Zenker, Charlotte M Niemeyer, Marry M van den Heuvel-Eibrink.
Abstract
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.Entities:
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Year: 2007 PMID： 18024410 DOI： 10.3324/haematol.11493
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941