| Literature DB >> 18024139 |
Radka Václavíková1, Eliska Kondrová, Marie Ehrlichová, Ahcene Boumendjel, Jan Kovár, Pavel Stopka, Pavel Soucek, Ivan Gut.
Abstract
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.Entities:
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Year: 2007 PMID： 18024139 DOI： 10.1016/j.bmc.2007.10.093
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641