| Literature DB >> 18024097 |
Gary Brooke1, Matthew Cook, Chris Blair, Rachel Han, Celena Heazlewood, Ben Jones, Melinda Kambouris, Kate Kollar, Steven McTaggart, Rebecca Pelekanos, Alison Rice, Tony Rossetti, Kerry Atkinson.
Abstract
Mesenchymal stromal cells (MSC) are multipotent cells that can be derived from many different organs and tissues. They have been demonstrated to play a role in tissue repair and regeneration in both preclinical and clinical studies. They also have remarkable immunosuppressive properties. We describe their application in settings that include the cardiovascular, central nervous, gastrointestinal, renal, orthopaedic and haematopoietic systems. Manufacturing of MSC for clinical trials is also discussed. Since tissue matching between MSC donor and recipient does not appear to be required, MSC may be the first cell type able to be used as an "off-the-shelf" therapeutic product.Entities:
Mesh：
Year: 2007 PMID： 18024097 DOI： 10.1016/j.semcdb.2007.09.012
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727