| Literature DB >> 18024033 |
Oscar Rebollo1, Esther del Olmo, Grace Ruiz, José L López-Pérez, Alberto Giménez, Arturo San Feliciano.
Abstract
A number of aminoalcohols, diamines and other related cycloanalogues of sphingosine have been synthesized and assayed in vitro against three Leishmania spp. and Trypanosoma cruzi. Most of the compounds were potent parasiticides, with IC50 values in the microM or lower range and potencies higher than those of pentamidine and benznidazol, the common therapeutic agents against these parasitoses.Entities:
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Year: 2007 PMID： 18024033 DOI： 10.1016/j.bmcl.2007.10.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823