Literature DB >> 18023932

Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor.

Eun Young Song1, Navneet Kaur, Mi-Young Park, Yinglan Jin, Kyeong Lee, Guncheol Kim, Ki Youn Lee, Jee Sun Yang, Jae Hong Shin, Ky-Youb Nam, Kyoung Tai No, Gyoonhee Han.   

Abstract

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

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Year:  2007        PMID： 18023932     DOI： 10.1016/j.ejmech.2007.10.008

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

1.  A novel inhibitor of Rho GDP-dissociation inhibitor α improves the therapeutic efficacy of paclitaxel in Lewis lung carcinoma.

Authors:  Xing Chen Peng; Xu Xia Chen; Y U Zhang; Hai Jun Wang; You Feng
Journal:  Biomed Rep       Date:  2015-05-27

2.  High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv.

Authors:  Robert C Reynolds; Subramaniam Ananthan; Ellen Faaleolea; Judith V Hobrath; Cecil D Kwong; Clinton Maddox; Lynn Rasmussen; Melinda I Sosa; Elizabeth Thammasuvimol; E Lucile White; Wei Zhang; John A Secrist
Journal:  Tuberculosis (Edinb)       Date:  2011-06-25       Impact factor: 3.131

3.  1-(3-Chloro-phen-yl)-3-(4-nitro-phen-yl)urea.

Authors:  Ting Sun; Jing Li; Feng-Ling Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-13

4.  SKLB-163, a new benzothiazole-2-thiol derivative, exhibits potent anticancer activity by affecting RhoGDI/JNK-1 signaling pathway.

Authors:  X Peng; G Xie; Z Wang; H Lin; T Zhou; P Xiang; Y Jiang; S Yang; Y Wei; L Yu; Y Zhao
Journal:  Cell Death Dis       Date:  2014-03-27       Impact factor: 8.469

5.  Synthesis and biological evaluation of novel benzothiazole-2-thiol derivatives as potential anticancer agents.

Authors:  Xuan-Hong Shi; Zhao Wang; Yong Xia; Ting-Hong Ye; Mei Deng; You-Zhi Xu; Yu-Quan Wei; Luo-Ting Yu
Journal:  Molecules       Date:  2012-03-30       Impact factor: 4.411

6.  Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities.

Authors:  Aliasghar Jarrahpour; Roghayeh Heiran; Véronique Sinou; Christine Latour; Lamia Djouhri Bouktab; Jean Michel Brunel; Javed Sheikh; Taibi Ben Hadda
Journal:  Iran J Pharm Res       Date:  2019       Impact factor: 1.696

7.  A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles.

Authors:  Mudzuli Maphupha; Wanyama P Juma; Charles B de Koning; Dean Brady
Journal:  RSC Adv       Date:  2018-11-27       Impact factor: 4.036

8.  Applying ligands profiling using multiple extended electron distribution based field templates and feature trees similarity searching in the discovery of new generation of urea-based antineoplastic kinase inhibitors.

Authors:  Eman M Dokla; Amr H Mahmoud; Mohamed S A Elsayed; Ahmed H El-Khatib; Michael W Linscheid; Khaled A Abouzid
Journal:  PLoS One       Date:  2012-11-20       Impact factor: 3.240

9.  A novel benzothiazole derivative YLT322 induces apoptosis via the mitochondrial apoptosis pathway in vitro with anti-tumor activity in solid malignancies.

Authors:  Song Xuejiao; Xia Yong; Wang Ningyu; Zhang Lidan; Shi Xuanhong; Xu Youzhi; Ye Tinghong; Shi Yaojie; Zhu Yongxia; Yu Luoting
Journal:  PLoS One       Date:  2013-05-30       Impact factor: 3.240

10.  Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment.

Authors:  Monika Schmidt; Ondrej Benek; Lucie Vinklarova; Martina Hrabinova; Lucie Zemanova; Matej Chribek; Vendula Kralova; Lukas Hroch; Rafael Dolezal; Antonin Lycka; Lukas Prchal; Daniel Jun; Laura Aitken; Frank Gunn-Moore; Kamil Kuca; Kamil Musilek
Journal:  Int J Mol Sci       Date:  2020-03-17       Impact factor: 5.923
  10 in total

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