| Literature DB >> 180229 |
K Kawashima, H Ikeda, E Stockert, T Takahashi, L J Old.
Abstract
Thymocytes from preleukemic AKR mice aged 5-6 mo have an altered pattern of cell surface antigens. The expression of four MuLV-related antigens on the cell surface (GIX, GCSA, gp70, p30) is markedly increased in comparison to 2-mo-old AKR mice and approximates the heightened levels of these antigens found on thymic leukemia cells. H-2 and Thy-1 alloantigens also show characteristic modifications in relation to age and leukemia development. In contrast to the high Thy-1/low H-2 levels on 2-mo-old AKR thymocytes, thymocytes from 6-mo-old mice and thymic leukemia cells frequently show a low Thy-1/high H-2 surface phenotype. As thymocytes from mouse strains with a low incidence of leukemia do not show these changes, they appear to represent a stage in the conversion of normal cells to leukemia cells.Entities:
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Year: 1976 PMID： 180229 PMCID： PMC2190365 DOI： 10.1084/jem.144.1.193
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307