Sex differences in response to an observational fear conditioning procedure.

The present study evaluated sex differences in observational fear conditioning using modeled "mock" panic attacks as an unconditioned stimulus (UCS). Fifty-nine carefully prescreened healthy undergraduate participants (30 women) underwent 3 consecutive differential conditioning phases: habituation, acquisition, and extinction. It was expected that participants watching a confederate display mock panic attacks (UCS) paired with a previously neutral stimulus (CS(+)) would learn to respond fearfully to the CS(+), but not to the CS(-) (i.e., a stimulus never associated with displays of panic). Women also were expected to report more distress and ratings of panic to the CS(+) than the CS(-) compared to men, but no sex differences were anticipated on autonomic indices of conditioning (i.e., electrodermal responses). Consistent with expectation, aversive conditioning was demonstrated by greater magnitude electrodermal and verbal-evaluative (e.g., subjective units of distress scale, panic ratings) responses to the CS(+) over the CS(-), with women reporting more distress to the CS(+) over the CS(-), but not greater autonomic conditioning, compared to men. Overall, the results support the notion that modeled panic attacks can serve as a potent UCS for both men and women. Discussion focuses on sex differences in observational fear conditioning and its relation to the clinical presentation of anxiety disorders.

RCT Entities:   Population Interventions Outcomes