BACKGROUND: The effect of eccentric exercise on the time-course changes in several indices of muscle damage and blood oxidative stress was examined. MATERIALS AND METHODS: Isometric torque, delayed-onset muscle soreness, creatine kinase, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric-acid reactive substances (TBARS), protein carbonyls, catalase, uric acid, bilirubin and total antioxidant capacity (TAC) in blood were measured pre-, 24 h, 48 h and 72 h post-eccentric exercise of knee extensors in ten females. RESULTS: The concentration of all oxidative stress indices changed significantly in a way indicating increased oxidative stress in the blood (GSH and GSH/GSSG, decreased, whereas GSSG, TBARS, protein carbonyls, catalase, uric acid, bilirubin and TAC increased) peaking, in all but TBARS, at 48 h and returning toward baseline afterwards. CONCLUSION: We believe that muscle-damaging exercise should be viewed as a different challenge compared to non-muscle-damaging exercise with regard to its effects on blood oxidative stress.
BACKGROUND: The effect of eccentric exercise on the time-course changes in several indices of muscle damage and blood oxidative stress was examined. MATERIALS AND METHODS: Isometric torque, delayed-onset muscle soreness, creatine kinase, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric-acid reactive substances (TBARS), protein carbonyls, catalase, uric acid, bilirubin and total antioxidant capacity (TAC) in blood were measured pre-, 24 h, 48 h and 72 h post-eccentric exercise of knee extensors in ten females. RESULTS: The concentration of all oxidative stress indices changed significantly in a way indicating increased oxidative stress in the blood (GSH and GSH/GSSG, decreased, whereas GSSG, TBARS, protein carbonyls, catalase, uric acid, bilirubin and TAC increased) peaking, in all but TBARS, at 48 h and returning toward baseline afterwards. CONCLUSION: We believe that muscle-damaging exercise should be viewed as a different challenge compared to non-muscle-damaging exercise with regard to its effects on blood oxidative stress.
Authors: C J Malavaki; G K Sakkas; G I Mitrou; A Kalyva; I Stefanidis; K H Myburgh; C Karatzaferi Journal: J Muscle Res Cell Motil Date: 2016-01-04 Impact factor: 2.698
Authors: Vassilis Paschalis; Anastasios A Theodorou; George Panayiotou; Antonios Kyparos; Dimitrios Patikas; Gerasimos V Grivas; Michalis G Nikolaidis; Ioannis S Vrabas Journal: PLoS One Date: 2013-02-21 Impact factor: 3.240