Charlotte M Poloschek1, Lutz L Hansen, Michael Bach. 1. Department of Ophthalmology, University of Freiburg, Killianstr. 5, 79106 Freiburg, Germany. charlotte.poloschek@uniklinik-freiburg.de
Abstract
PURPOSE: To present a case of macular dystrophy with early changes in fundus autofluorescence. METHODS: A 20-year-old woman with a recent loss of visual acuity and onset of photophobia was examined. Color vision and visual field testing, fluorescein angiography, full-field and multifocal electroretinograms as well as fundus autofluorescence were performed. RESULTS: Best-corrected visual acuity was 20/100 (right eye) and 20/60 (left eye). There was a red-green color vision defect and a relative central scotoma in both eyes. Ophthalmoscopy and fluorescein angiography were essentially normal, the presence of a dark choroid was debatable. Full-field ERG responses were normal, but the multifocal ERG showed severely reduced responses in the macular region. Both eyes showed a slight circular parafoveolar increase of fundus autofluorescence. CONCLUSION: Besides multifocal ERG, fundus autofluorescence aids to objectively assess the manifestation of macular dystrophies but does not discern between different types in early stages.
PURPOSE: To present a case of macular dystrophy with early changes in fundus autofluorescence. METHODS: A 20-year-old woman with a recent loss of visual acuity and onset of photophobia was examined. Color vision and visual field testing, fluorescein angiography, full-field and multifocal electroretinograms as well as fundus autofluorescence were performed. RESULTS: Best-corrected visual acuity was 20/100 (right eye) and 20/60 (left eye). There was a red-green color vision defect and a relative central scotoma in both eyes. Ophthalmoscopy and fluorescein angiography were essentially normal, the presence of a dark choroid was debatable. Full-field ERG responses were normal, but the multifocal ERG showed severely reduced responses in the macular region. Both eyes showed a slight circular parafoveolar increase of fundus autofluorescence. CONCLUSION: Besides multifocal ERG, fundus autofluorescence aids to objectively assess the manifestation of macular dystrophies but does not discern between different types in early stages.
Authors: Neil D Ebenezer; Michel Michaelides; Sharon A Jenkins; Isabelle Audo; Andrew R Webster; Michael E Cheetham; Andrew Stockman; Eamonn R Maher; John R Ainsworth; John R Yates; Keith Bradshaw; Graham E Holder; Anthony T Moore; Alison J Hardcastle Journal: Invest Ophthalmol Vis Sci Date: 2005-06 Impact factor: 4.799