Literature DB >> 18007470

Synthesis of some novel 11b-substituted pyrimido[6,1-a]-isoquinoline derivatives.

Plamen A Angelov1, Iliyan I Ivanov, Atanas P Venkov.   

Abstract

A series of novel 11b-substituted 1,6,7,11b-tetrahydropyrimido[6,1-a]- isoquinoline-2,4-diones and 4-thioxo-1,3,4,6,7,11b-hexahydropyrimido[6,1-a]isoquinolin-2- ones were synthesized, utilizing two alternative strategies for ring closure of tetrahydroisoquinoline intermediates obtained from N-phenethyl enaminones.

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Year:  2004        PMID： 18007470      PMCID： PMC6147284          DOI： 10.3390/90800694

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  2 in total

1.  HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro.

Authors:  D Ruppert; K U Weithmann
Journal:  Life Sci       Date:  1982-11-08       Impact factor: 5.037

2.  Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-py rim ido [6,1-a]isoquinolin-4-ones.

Authors:  B Lal; A N Dohadwalla; N K Dadkar; A D'Sa; N J de Souza
Journal:  J Med Chem       Date:  1984-11       Impact factor: 7.446
  2 in total
  1 in total

1.  Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds.

Authors:  Brett A Granger; Kyosuke Kaneda; Stephen F Martin
Journal:  Org Lett       Date:  2011-08-11       Impact factor: 6.005
  1 in total

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