Literature DB >> 18007414

Structure-activity relationships for the 9-(pyridin-2'-yl)- aminoacridines.

Michael D Mosher1, Kristi L Holmes, Katherine S Frost.   

Abstract

A series of 9-(pyridin-2'-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.

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Year:  2004        PMID： 18007414      PMCID： PMC6147285          DOI： 10.3390/90300102

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  7 in total

1.  Thiolytic cleavage of the anti-tumour compound 4'-(9-acridinylamino)-methanesulphon-m-anisidine (m-AMSA, NSC 156 303) in blood.

Authors:  W B Wilson; B F Cain; B C Baguley
Journal:  Chem Biol Interact       Date:  1977-08       Impact factor: 5.192

2.  Potential antitumor agents. 12. 9-Anilinoacridines.

Authors:  G J Atwell; B F Cain; R N Seelye
Journal:  J Med Chem       Date:  1972-06       Impact factor: 7.446

Review 3.  m-AMSA: a review of clinical data.

Authors:  R Zittoun
Journal:  Eur J Cancer Clin Oncol       Date:  1985-06

4.  Potential antitumor agents. 32. Role of agent base strength in the quantitative structure--antitumor relationships for 4'-(9-acridinylamino)methanesulfonanilide analogues.

Authors:  W A Denny; G J Atwell; B F Cain
Journal:  J Med Chem       Date:  1979-12       Impact factor: 7.446

5.  Measles outbreak among internationally adopted children arriving in the United States, February-March 2001.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2002-12-13       Impact factor: 17.586

6.  Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

Authors:  E M Nelson; K M Tewey; L F Liu
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

7.  Synthesis, DNA-binding and biological activity of a double intercalating analog of ethidium bromide.

Authors:  K F Kuhlmann; N J Charbeneau; C W Mosher
Journal:  Nucleic Acids Res       Date:  1978-07       Impact factor: 16.971
  7 in total

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