Literature DB >> 18007401

Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid.

Mario Sechi1, Fabio Casu, Ilaria Campesi, Stefano Fiori, Alberto Mariani.   

Abstract

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.

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Year:  2006        PMID： 18007401      PMCID： PMC6148522          DOI： 10.3390/11120968

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


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