AIMS: The aim of the study is to assess pupil size changes and mobility evaluation as a diagnostic marker in patients with probable Alzheimer's disease (AD). MATERIAL AND METHODS: Twenty-three control subjects and 23 patients with probable AD entered the study. The latter patients had been under observation for 2 years and had undergone all necessary examinations to verify their initial diagnosis. A full record of the pupil's reaction to light was registered. Ten parameters from these data were measured, reported and then compared in both group of subjects. RESULTS: Patients with probable AD had abnormal pupillary function compared with such function in healthy aging. All pupillary light reflex (PLR) variables differed significantly between the two groups (p<0.005) except baseline pupil diameter (D1) and minimum pupil diameter (D2). Maximum constriction acceleration (ACmax) was the best predictor in classifying a subject as normal or as AD with perfect classification ability (area under the curve =1, p<0.001). In addition, the correlation between the percentage recovery-redilatation (%D1) and ACmax was highly negative in the group of AD patients (r = -0.808, p<0.005). CONCLUSIONS: Pupil size changes and mobility examination may be a fast, non-invasive and efficient additional diagnostic marker in AD diagnosis.
AIMS: The aim of the study is to assess pupil size changes and mobility evaluation as a diagnostic marker in patients with probable Alzheimer's disease (AD). MATERIAL AND METHODS: Twenty-three control subjects and 23 patients with probable AD entered the study. The latter patients had been under observation for 2 years and had undergone all necessary examinations to verify their initial diagnosis. A full record of the pupil's reaction to light was registered. Ten parameters from these data were measured, reported and then compared in both group of subjects. RESULTS:Patients with probable AD had abnormal pupillary function compared with such function in healthy aging. All pupillary light reflex (PLR) variables differed significantly between the two groups (p<0.005) except baseline pupil diameter (D1) and minimum pupil diameter (D2). Maximum constriction acceleration (ACmax) was the best predictor in classifying a subject as normal or as AD with perfect classification ability (area under the curve =1, p<0.001). In addition, the correlation between the percentage recovery-redilatation (%D1) and ACmax was highly negative in the group of ADpatients (r = -0.808, p<0.005). CONCLUSIONS: Pupil size changes and mobility examination may be a fast, non-invasive and efficient additional diagnostic marker in AD diagnosis.
Authors: Ling Bei; Ying-Bo Shui; Fang Bai; Suzanne K Nelson; Gregory P Van Stavern; David C Beebe Journal: Exp Eye Res Date: 2015-03-13 Impact factor: 3.467
Authors: Shaun M Frost; Yogesan Kanagasingam; Hamid R Sohrabi; Kevin Taddei; Randall Bateman; John Morris; Tammie Benzinger; Alison Goate; Colin L Masters; Ralph N Martins Journal: Curr Alzheimer Res Date: 2013-10 Impact factor: 3.498
Authors: Umma Habiba; Joseph Descallar; Fabian Kreilaus; Utpal K Adhikari; Sachin Kumar; John W Morley; Bang V Bui; Maya Koronyo-Hamaoui; Mourad Tayebi Journal: Alzheimers Dement (Amst) Date: 2021-05-06