BACKGROUND: Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of glioma patients; however, malignant melanoma has consistently been described. METHODS: We obtained family history information from 1,476 glioma patients under age 75 years who registered at M. D. Anderson Cancer Center between June 1992 and June 2006. The number of observed cancers (N=1,001) among 8,746 first-degree relatives (FDR) was compared with the number expected from age-, sex-, and calendar year-specific rates from the Surveillance, Epidemiology, and End Results Program using standardized incidence ratios (SIR). RESULTS: The overall SIR for any cancer was 1.21 (95% confidence interval, 1.14-1.29). Among FDRs under 45 years the overall SIR was 5.08, and for relatives >45 years the overall SIR was 0.95. The SIRs were significantly elevated for brain tumors (2.14), melanoma (2.02), and sarcoma (3.83). We observed an excess of pancreatic cancer, which was significantly higher only among mothers. CONCLUSION: We observed an overall 21% increase in cancer among the FDRs of glioma patients including excess cases of brain tumors and melanoma, which could point to similar genetic contributions to these two malignancies. A large international linkage study is under way to examine potential genomic regions important for familial glioma.
BACKGROUND: Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of gliomapatients; however, malignant melanoma has consistently been described. METHODS: We obtained family history information from 1,476 gliomapatients under age 75 years who registered at M. D. Anderson Cancer Center between June 1992 and June 2006. The number of observed cancers (N=1,001) among 8,746 first-degree relatives (FDR) was compared with the number expected from age-, sex-, and calendar year-specific rates from the Surveillance, Epidemiology, and End Results Program using standardized incidence ratios (SIR). RESULTS: The overall SIR for any cancer was 1.21 (95% confidence interval, 1.14-1.29). Among FDRs under 45 years the overall SIR was 5.08, and for relatives >45 years the overall SIR was 0.95. The SIRs were significantly elevated for brain tumors (2.14), melanoma (2.02), and sarcoma (3.83). We observed an excess of pancreatic cancer, which was significantly higher only among mothers. CONCLUSION: We observed an overall 21% increase in cancer among the FDRs of gliomapatients including excess cases of brain tumors and melanoma, which could point to similar genetic contributions to these two malignancies. A large international linkage study is under way to examine potential genomic regions important for familial glioma.
Authors: M J Bello; J M de Campos; J Vaquero; M E Kusak; J L Sarasa; A Pestaña; J A Rey Journal: Genes Chromosomes Cancer Date: 1994-01 Impact factor: 5.006
Authors: Niina Paunu; Eero Pukkala; Pekka Laippala; Risto Sankila; Jorma Isola; Helena Miettinen; Kalle O J Simola; Pauli Helén; Heikki Helin; Hannu Haapasalo Journal: Int J Cancer Date: 2002-02-20 Impact factor: 7.396
Authors: Brian P O'Neill; Hannes Blondal; Ping Yang; Gurri H Olafsdottir; H Sigvaldason; Robert B Jenkins; David W Kimmel; Bernd W Scheithauer; Walter A Rocca; Johannes Bjornsson; Hfran Tulinius Journal: Cancer Epidemiol Biomarkers Prev Date: 2002-09 Impact factor: 4.254
Authors: L A Cannon-Albright; D E Goldgar; L J Meyer; C M Lewis; D E Anderson; J W Fountain; M E Hegi; R W Wiseman; E M Petty; A E Bale Journal: Science Date: 1992-11-13 Impact factor: 47.728
Authors: Deirdre A Hill; Peter D Inskip; William R Shapiro; Robert G Selker; Howard A Fine; Peter M Black; Martha S Linet Journal: Cancer Epidemiol Biomarkers Prev Date: 2003-12 Impact factor: 4.254
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Authors: Jennifer Permuth-Wey; Reid C Thompson; L Burton Nabors; Jeffrey J Olson; James E Browning; Melissa H Madden; Y Ann Chen; Kathleen M Egan Journal: J Neurooncol Date: 2011-07-09 Impact factor: 4.130
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Authors: Michael E Scheurer; Carol J Etzel; Mei Liu; Jill Barnholtz-Sloan; Fredrik Wiklund; Björn Tavelin; Margaret R Wrensch; Beatrice S Melin; Melissa L Bondy Journal: Am J Epidemiol Date: 2010-09-21 Impact factor: 4.897
Authors: Preetha Rajaraman; Beatrice S Melin; Zhaoming Wang; Roberta McKean-Cowdin; Dominique S Michaud; Sophia S Wang; Melissa Bondy; Richard Houlston; Robert B Jenkins; Margaret Wrensch; Meredith Yeager; Anders Ahlbom; Demetrius Albanes; Ulrika Andersson; Laura E Beane Freeman; Julie E Buring; Mary Ann Butler; Melissa Braganza; Tania Carreon; Maria Feychting; Sarah J Fleming; Susan M Gapstur; J Michael Gaziano; Graham G Giles; Goran Hallmans; Roger Henriksson; Judith Hoffman-Bolton; Peter D Inskip; Christoffer Johansen; Cari M Kitahara; Mark Lathrop; Chenwei Liu; Loic Le Marchand; Martha S Linet; Stefan Lonn; Ulrike Peters; Mark P Purdue; Nathaniel Rothman; Avima M Ruder; Marc Sanson; Howard D Sesso; Gianluca Severi; Xiao-Ou Shu; Matthias Simon; Meir Stampfer; Victoria L Stevens; Kala Visvanathan; Emily White; Alicja Wolk; Anne Zeleniuch-Jacquotte; Wei Zheng; Paul Decker; Victor Enciso-Mora; Brooke Fridley; Yu-Tang Gao; Matthew Kosel; Daniel H Lachance; Ching Lau; Terri Rice; Anthony Swerdlow; Joseph L Wiemels; John K Wiencke; Sanjay Shete; Yong-Bing Xiang; Yuanyuan Xiao; Robert N Hoover; Joseph F Fraumeni; Nilanjan Chatterjee; Patricia Hartge; Stephen J Chanock Journal: Hum Genet Date: 2012-08-11 Impact factor: 4.132
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