Literature DB >> 18005745

Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites.

Samuel D Dean1, Keith R Matthews.   

Abstract

Trypanosomes evade antibody-mediated lysis via antigenic variation and rapid antibody removal from their cell surface. Recently, in Cell, Engstler et al. (2007) have discovered the mechanism for antibody clearance. Hydrodynamic forces generated by trypanosome swimming create a current, causing surface-bound antibodies to act as "molecular sails." Consequently, they are swept to the cell posterior, internalized via the flagellar-pocket, and degraded. Hydrodynamic sorting is a novel biological process, possibly applicable in other contexts.

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Year:  2007        PMID： 18005745      PMCID： PMC2855961          DOI： 10.1016/j.chom.2007.10.006

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  10 in total

Review 1.  Antigenic variation in African trypanosomes: monitoring progress.

Authors:  Richard McCulloch
Journal:  Trends Parasitol       Date:  2004-03

2.  Conserved and specific functions of axoneme components in trypanosome motility.

Authors:  Carole Branche; Linda Kohl; Géraldine Toutirais; Johanna Buisson; Jacky Cosson; Philippe Bastin
Journal:  J Cell Sci       Date:  2006-08-01       Impact factor: 5.285

3.  Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes.

Authors:  Markus Engstler; Thomas Pfohl; Stephan Herminghaus; Michael Boshart; Geert Wiegertjes; Niko Heddergott; Peter Overath
Journal:  Cell       Date:  2007-11-02       Impact factor: 41.582

4.  Activation of endocytosis as an adaptation to the mammalian host by trypanosomes.

Authors:  Senthil Kumar A Natesan; Lori Peacock; Keith Matthews; Wendy Gibson; Mark C Field
Journal:  Eukaryot Cell       Date:  2007-09-28

5.  Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation.

Authors:  Katrina A Lythgoe; Liam J Morrison; Andrew F Read; J David Barry
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-26       Impact factor: 11.205

6.  Trypanosoma brucei: fluxes of the morphological variants in intact and X-irradiated mice.

Authors:  A E Balber
Journal:  Exp Parasitol       Date:  1972-04       Impact factor: 2.011

Review 7.  The developmental cell biology of Trypanosoma brucei.

Authors:  Keith R Matthews
Journal:  J Cell Sci       Date:  2005-01-15       Impact factor: 5.285

8.  Comparison of the effects of immune killing mechanisms on Trypanosoma brucei parasites of slender and stumpy morphology.

Authors:  L M McLintock; C M Turner; K Vickerman
Journal:  Parasite Immunol       Date:  1993-08       Impact factor: 2.280

9.  Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei.

Authors:  Markus Engstler; Lutz Thilo; Frank Weise; Christoph G Grünfelder; Heinz Schwarz; Michael Boshart; Peter Overath
Journal:  J Cell Sci       Date:  2004-03-01       Impact factor: 5.285

10.  The GPI-phospholipase C of Trypanosoma brucei is nonessential but influences parasitemia in mice.

Authors:  H Webb; N Carnall; L Vanhamme; S Rolin; J Van Den Abbeele; S Welburn; E Pays; M Carrington
Journal:  J Cell Biol       Date:  1997-10-06       Impact factor: 10.539
  10 in total
  6 in total

1.  Tsetse GmmSRPN10 has anti-complement activity and is important for successful establishment of trypanosome infections in the fly midgut.

Authors:  Cher-Pheng Ooi; Lee R Haines; Daniel M Southern; Michael J Lehane; Alvaro Acosta-Serrano
Journal:  PLoS Negl Trop Dis       Date:  2015-01-08

Review 2.  Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis.

Authors:  Benoit Stijlemans; Patrick De Baetselier; Guy Caljon; Jan Van Den Abbeele; Jo A Van Ginderachter; Stefan Magez
Journal:  Front Immunol       Date:  2017-06-30       Impact factor: 7.561

Review 3.  Structure, function and druggability of the African trypanosome flagellum.

Authors:  Julia Sáez Conde; Samuel Dean
Journal:  J Cell Physiol       Date:  2022-05-26       Impact factor: 6.513

4.  The limits on trypanosomatid morphological diversity.

Authors:  Richard John Wheeler; Eva Gluenz; Keith Gull
Journal:  PLoS One       Date:  2013-11-19       Impact factor: 3.240

Review 5.  The Trypanosome Flagellar Pocket Collar and Its Ring Forming Protein-TbBILBO1.

Authors:  Doranda Perdomo; Mélanie Bonhivers; Derrick R Robinson
Journal:  Cells       Date:  2016-03-02       Impact factor: 6.600

Review 6.  Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System.

Authors:  Stefan Magez; Joar Esteban Pinto Torres; Emmanuel Obishakin; Magdalena Radwanska
Journal:  Front Immunol       Date:  2020-03-11       Impact factor: 7.561
  6 in total

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