| Literature DB >> 18005719 |
Abdul A Waheed1, Eric O Freed.
Abstract
Interferons elicit antiviral responses by inducing the expression of a large number of host cell genes. In this issue of Cell Host & Microbe, Wang and colleagues report that the interferon-inducible protein viperin inhibits influenza A virus release by impairing the formation of cholesterol-enriched plasma membrane microdomains, or lipid rafts. Viperin appears to disrupt lipid rafts by suppressing the activity of farnesyl diphosphate synthase, a key enzyme in isoprenoid biosynthesis.Entities:
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Year: 2007 PMID： 18005719 DOI： 10.1016/j.chom.2007.07.005
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023