| Literature DB >> 18005705 |
Abstract
How probiotics such as Bacillus subtilis exert a protective effect has been much debated. In this issue of Cell Host & Microbe, Fujiya et al. reveal that a B. subtilis quorum-sensing signal molecule, the competence- and sporulation-stimulating factor (CSF), is internalized via the mammalian oligopeptide transporter OCTN2, where it induces the heat shock protein Hsp27, which protects intestinal cells against oxidant-mediated tissue damage and loss of barrier function.Entities:
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Year: 2007 PMID： 18005705 DOI： 10.1016/j.chom.2007.05.010
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023