BACKGROUND: The incidence of Crohn's disease rose rapidly in industralized countries over the past 50 years, but it is unclear whether the incidence is still rising or has reached a plateau. AIMS: To update the long-term incidence study of Crohn's disease in Cardiff for 1996-2005, to investigate whether incidence is still rising and to study changes in disease characteristics over time. METHOD: Crohn's cases identified by retrospective analysis of hospital records as in previous studies in Cardiff. RESULTS: Two hundred and twelve cases were identified. Corrected incidence for this decade was 66 x 10(6) per year (95% confidence interval: 58-76), showing a continuing rise compared to previous decades. The proportion with colonic disease at presentation continues to rise (43%) with a corresponding fall in those with terminal ileal disease. There remains a strong female preponderance (F:M 1.6:1) as in previous studies. The incidence in children under age 16 continues to rise, and the median age at diagnosis has fallen slightly. CONCLUSION: Crohn's disease incidence continues to rise slowly in Cardiff with a continuing increase in those presenting with colonic disease, which is now the commonest disease pattern.
BACKGROUND: The incidence of Crohn's disease rose rapidly in industralized countries over the past 50 years, but it is unclear whether the incidence is still rising or has reached a plateau. AIMS: To update the long-term incidence study of Crohn's disease in Cardiff for 1996-2005, to investigate whether incidence is still rising and to study changes in disease characteristics over time. METHOD: Crohn's cases identified by retrospective analysis of hospital records as in previous studies in Cardiff. RESULTS: Two hundred and twelve cases were identified. Corrected incidence for this decade was 66 x 10(6) per year (95% confidence interval: 58-76), showing a continuing rise compared to previous decades. The proportion with colonic disease at presentation continues to rise (43%) with a corresponding fall in those with terminal ileal disease. There remains a strong female preponderance (F:M 1.6:1) as in previous studies. The incidence in children under age 16 continues to rise, and the median age at diagnosis has fallen slightly. CONCLUSION:Crohn's disease incidence continues to rise slowly in Cardiff with a continuing increase in those presenting with colonic disease, which is now the commonest disease pattern.
Authors: Lori A Button; Stephen E Roberts; Michael J Goldacre; Ashley Akbari; Sarah E Rodgers; John G Williams Journal: World J Gastroenterol Date: 2010-01-28 Impact factor: 5.742
Authors: Maria Laura Santoru; Cristina Piras; Antonio Murgia; Vanessa Palmas; Tania Camboni; Sonia Liggi; Ivan Ibba; Maria Antonia Lai; Sandro Orrù; Sylvain Blois; Anna Lisa Loizedda; Julian Leether Griffin; Paolo Usai; Pierluigi Caboni; Luigi Atzori; Aldo Manzin Journal: Sci Rep Date: 2017-08-25 Impact factor: 4.379
Authors: Ayesha Shah; Nicholas J Talley; Marjorie Walker; Natasha Koloski; Mark Morrison; Daniel Burger; Jane M Andrews; Michael McGuckin; Mike Jones; Gerald Holtmann Journal: Dig Dis Sci Date: 2017-03-09 Impact factor: 3.199