Development of microbial sensors and their application.

Many types of microbial sensors have been developed as analytical tools since the first microbial sensor was studied by Karube et al. in 1977. The microbial sensor consists of a transducer and microbe as a sensing element. The characteristics of the microbial sensors are a complete contrast to those of enzyme sensors or immunosensors, which are highly specific for the substrates of interest, although the specificity of the microbial sensor has been improved by genetic modification of the microbe used as the sensing element. Microbial sensors have the advantages of tolerance to measuring conditions, a long lifetime, and cost performance, and also have the disadvantage of a long response time. In this review, the long history of microbial sensor development is summarized.