Literature DB >> 18004514

Novel therapies targeting the apoptosis pathway for the treatment of acute myeloid leukemia.

Aaron D Schimmer1.   

Abstract

Defects in the core regulators of the apoptosis pathway contribute to chemoresistance and poor outcomes in patients with acute myeloid leukemia (AML). To overcome these defects, novel molecules that target key proteins in the mitochondrial, death receptor, and convergence pathways of caspase activation are being developed. This review will highlight selected molecules including Bcl-2 and XIAP inhibitors that are advanced stages of development and have entered clinical trial for AML. In addition, this review will discuss how these novel therapies are being used as chemical probes to better understand the biology of the apoptosis pathway.

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Year:  2007        PMID： 18004514     DOI： 10.1007/s11864-007-0037-x

Source DB:  PubMed          Journal:  Curr Treat Options Oncol        ISSN： 1534-6277


  48 in total

Review 1.  Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities.

Authors:  J C Reed
Journal:  Cell Death Differ       Date:  2006-06-02       Impact factor: 15.828

2.  BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute myelogenous leukemia.

Authors:  S M Kornblau; H T Vu; P Ruvolo; Z Estrov; S O'Brien; J Cortes; H Kantarjian; M Andreeff; W S May
Journal:  Clin Cancer Res       Date:  2000-04       Impact factor: 12.531

3.  Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia.

Authors:  Susan O'Brien; Joseph O Moore; Thomas E Boyd; Loree M Larratt; Aleksander Skotnicki; Benjamin Koziner; Asher A Chanan-Khan; John F Seymour; R Gregory Bociek; Steve Pavletic; Kanti R Rai
Journal:  J Clin Oncol       Date:  2007-02-12       Impact factor: 44.544

4.  Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells.

Authors:  Fei Guo; Celia Sigua; Jianguo Tao; Purva Bali; Prince George; Yunqing Li; Sylvie Wittmann; Lynn Moscinski; Peter Atadja; Kapil Bhalla
Journal:  Cancer Res       Date:  2004-04-01       Impact factor: 12.701

5.  Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.

Authors:  Melinda S Yates; Mi-Kyoung Kwak; Patricia A Egner; John D Groopman; Sridevi Bodreddigari; Thomas R Sutter; Karen J Baumgartner; B D Roebuck; Karen T Liby; Mark M Yore; Tadashi Honda; Gordon W Gribble; Michael B Sporn; Thomas W Kensler
Journal:  Cancer Res       Date:  2006-02-15       Impact factor: 12.701

6.  The triterpenoid CDDO induces apoptosis in refractory CLL B cells.

Authors:  Irene M Pedersen; Shinichi Kitada; Aaron Schimmer; Youngsoo Kim; Juan M Zapata; Lula Charboneau; Laura Rassenti; Michael Andreeff; Frank Bennett; Michael B Sporn; Lance D Liotta; Thomas J Kipps; John C Reed
Journal:  Blood       Date:  2002-10-15       Impact factor: 22.113

7.  A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

Authors:  N Suh; Y Wang; T Honda; G W Gribble; E Dmitrovsky; W F Hickey; R A Maue; A E Place; D M Porter; M J Spinella; C R Williams; G Wu; A J Dannenberg; K C Flanders; J J Letterio; D J Mangelsdorf; C F Nathan; L Nguyen; W W Porter; R F Ren; A B Roberts; N S Roche; K Subbaramaiah; M B Sporn
Journal:  Cancer Res       Date:  1999-01-15       Impact factor: 12.701

8.  Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1.

Authors:  Anthony W Tolcher; Monica Mita; Neal J Meropol; Margaret von Mehren; Amita Patnaik; Kristin Padavic; Monique Hill; Theresa Mays; Therese McCoy; Norma Lynn Fox; Wendy Halpern; Alfred Corey; Roger B Cohen
Journal:  J Clin Oncol       Date:  2007-04-10       Impact factor: 44.544

9.  Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Authors:  Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; York Tomita; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Journal:  J Med Chem       Date:  2004-08-12       Impact factor: 7.446

10.  HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.

Authors:  L Pukac; P Kanakaraj; R Humphreys; R Alderson; M Bloom; C Sung; T Riccobene; R Johnson; M Fiscella; A Mahoney; J Carrell; E Boyd; X T Yao; L Zhang; L Zhong; A von Kerczek; L Shepard; T Vaughan; B Edwards; C Dobson; T Salcedo; V Albert
Journal:  Br J Cancer       Date:  2005-04-25       Impact factor: 7.640
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  6 in total

Review 1.  Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.

Authors:  Prithviraj Bose; Yun Dai; Steven Grant
Journal:  Pharmacol Ther       Date:  2014-04-24       Impact factor: 12.310

2.  The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.

Authors:  M Abraham; S Klein; B Bulvik; H Wald; I D Weiss; D Olam; L Weiss; K Beider; O Eizenberg; O Wald; E Galun; A Avigdor; O Benjamini; A Nagler; Y Pereg; S Tavor; A Peled
Journal:  Leukemia       Date:  2017-03-10       Impact factor: 11.528

3.  CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak.

Authors:  Kimberly N Kremer; Kevin L Peterson; Paula A Schneider; X Wei Meng; Haiming Dai; Allan D Hess; B Douglas Smith; Christie Rodriguez-Ramirez; Judith E Karp; Scott H Kaufmann; Karen E Hedin
Journal:  J Biol Chem       Date:  2013-06-24       Impact factor: 5.157

4.  CD44 ligation with A3D8 antibody induces apoptosis in acute myeloid leukemia cells through binding to CD44s and clustering lipid rafts.

Authors:  Hao Qian; Lijuan Xia; Peixue Ling; Samuel Waxman; Yongkui Jing
Journal:  Cancer Biol Ther       Date:  2012-08-16       Impact factor: 4.742

Review 5.  Childhood acute myeloid leukemia.

Authors:  Jeffrey E Rubnitz
Journal:  Curr Treat Options Oncol       Date:  2008-05-28

6.  Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein.

Authors:  Chad M McKee; Yunchuan Ding; Jianfeng Zhou; Chunrui Li; Liang Huang; Xiangke Xin; Jing He; Joshua E Allen; Wafik S El-Deiry; Yunhong Cao; Ruth J Muschel; Danmei Xu
Journal:  Oncotarget       Date:  2015-02-28
  6 in total

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