OBJECTIVE: Homozygotes for the C-allele of the single nucleotide polymorphism (SNP) rs7566605, located approximately 10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese. The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype. RESEARCH DESIGN AND METHODS: We genotyped rs7566605 in 293 obese children (mean age 10.8 years, 45% male, mean BMI 28.1 kg/m(2)) who presented for a 1-year intervention. The reduction of SD score (SDS) BMI was compared based on an intention-to-treat analysis between the children with different genotypes. Blood pressure, triglycerides, insulin and glucose concentrations, and total, HDL, and LDL cholesterol were measured before and after intervention. RESULTS: After 1 year, obese children with the CC-genotype had reduced their SDS BMI to a lower extent than obese children with GC- or GG-genotypes (recessive model P = 0.007). There was no evidence for an association of rs7566605 with the cardiovascular risk factor profile (nominal P > 0.1). CONCLUSIONS: CC-homozygotes at SNP rs7566605 in the vicinity of INSIG2 lost less weight in this lifestyle intervention. This finding further implicates this polymorphism in weight regulation.
OBJECTIVE: Homozygotes for the C-allele of the single nucleotide polymorphism (SNP) rs7566605, located approximately 10 kb upstream of insulin-induced gene 2 (INSIG2), showed a slightly increased risk of becoming obese. The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype. RESEARCH DESIGN AND METHODS: We genotyped rs7566605 in 293 obesechildren (mean age 10.8 years, 45% male, mean BMI 28.1 kg/m(2)) who presented for a 1-year intervention. The reduction of SD score (SDS) BMI was compared based on an intention-to-treat analysis between the children with different genotypes. Blood pressure, triglycerides, insulin and glucose concentrations, and total, HDL, and LDL cholesterol were measured before and after intervention. RESULTS: After 1 year, obesechildren with the CC-genotype had reduced their SDS BMI to a lower extent than obesechildren with GC- or GG-genotypes (recessive model P = 0.007). There was no evidence for an association of rs7566605 with the cardiovascular risk factor profile (nominal P > 0.1). CONCLUSIONS: CC-homozygotes at SNP rs7566605 in the vicinity of INSIG2 lost less weight in this lifestyle intervention. This finding further implicates this polymorphism in weight regulation.
Authors: Daniele Campa; Anika Hüsing; James D McKay; Olga Sinilnikova; Ulla Vogel; Anne Tjønneland; Kim Overvad; Jakob Stegger; Françoise Clavel-Chapelon; Nathalie Chabbert-Buffet; Guy Fagherazzi; Antonia Trichopoulou; Dimosthenis Zylis; Erifili Oustoglou; Sabine Rohrmann; Birgit Teucher; Eva Fisher; Heiner Boeing; Giovanna Masala; Vittorio Krogh; Carlotta Sacerdote; Salvatore Panico; Rosario Tumino; N Charlotte Onland-Moret; Carla H van Gils; H Bas Bueno-de-Mesquita; Eiliv Lund; María Dolores Chirlaque; Núria Sala; José Ramon Quirós; Eva Ardanaz; Pilar Amiano; Esther Molina-Montes; Göran Hallmans; Per Lenner; Ruth C Travis; Timothy J Key; Nick Wareham; Kay-Tee Khaw; Sabina Rinaldi; Nadia Slimani; Veronique Chajes; Afshan Siddiq; Elio Riboli; Rudolf Kaaks; Federico Canzian Journal: BMC Cancer Date: 2010-10-18 Impact factor: 4.430
Authors: Matthew A Sabin; Susan L Clemens; Richard Saffery; Zoe McCallum; Michele W Campbell; Wieland Kiess; Nancy A Crimmins; Jessica G Woo; Gary M Leong; George A Werther; Obioha C Ukoumunne; Melissa A Wake Journal: BMC Med Res Methodol Date: 2010-10-22 Impact factor: 4.615
Authors: P W Franks; K A Jablonski; L M Delahanty; J B McAteer; S E Kahn; W C Knowler; J C Florez Journal: Diabetologia Date: 2008-10-07 Impact factor: 10.122
Authors: Iris M Heid; Cornelia Huth; Ruth J F Loos; Florian Kronenberg; Vera Adamkova; Sonia S Anand; Kristin Ardlie; Heike Biebermann; Peter Bjerregaard; Heiner Boeing; Claude Bouchard; Marina Ciullo; Jackie A Cooper; Dolores Corella; Christian Dina; James C Engert; Eva Fisher; Francesc Francès; Philippe Froguel; Johannes Hebebrand; Robert A Hegele; Anke Hinney; Margret R Hoehe; Frank B Hu; Jaroslav A Hubacek; Steve E Humphries; Steven C Hunt; Thomas Illig; Marjo-Riita Järvelin; Marika Kaakinen; Barbara Kollerits; Heiko Krude; Jitender Kumar; Leslie A Lange; Birgit Langer; Shengxu Li; Andreas Luchner; Helen N Lyon; David Meyre; Karen L Mohlke; Vincent Mooser; Almut Nebel; Thuy Trang Nguyen; Bernhard Paulweber; Louis Perusse; Lu Qi; Tuomo Rankinen; Dieter Rosskopf; Stefan Schreiber; Shantanu Sengupta; Rossella Sorice; Anita Suk; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Henry Völzke; Karani S Vimaleswaran; Nicholas J Wareham; Dawn Waterworth; Salim Yusuf; Cecilia Lindgren; Mark I McCarthy; Christoph Lange; Joel N Hirschhorn; Nan Laird; H-Erich Wichmann Journal: PLoS Genet Date: 2009-10-23 Impact factor: 5.917
Authors: Susanne Tan; André Scherag; Onno Eilard Janssen; Susanne Hahn; Harald Lahner; Tiina Dietz; Susann Scherag; Harald Grallert; Carla Ivane Ganz Vogel; Rainer Kimmig; Thomas Illig; Klaus Mann; Johannes Hebebrand; Anke Hinney Journal: BMC Med Genet Date: 2010-01-21 Impact factor: 2.103
Authors: Funda E Orkunoglu-Suer; Heather Gordish-Dressman; Priscilla M Clarkson; Paul D Thompson; Theodore J Angelopoulos; Paul M Gordon; Niall M Moyna; Linda S Pescatello; Paul S Visich; Robert F Zoeller; Brennan Harmon; Richard L Seip; Eric P Hoffman; Joseph M Devaney Journal: BMC Med Genet Date: 2008-12-23 Impact factor: 2.103