Literature DB >> 18003542

Micro-molded cannulae for intracochlear infusions in small rodents.

Dean G Johnson1, Xiao Xia Zhu, Robert D Frisina, David A Borkholder.   

Abstract

The design, fabrication, and testing of micro-cannulae with integrated insertion stops is presented. The micro-cannulae were engineered through the use of a silicon micro-mold fabricated via bulk-silicon micro-machining techniques. The use of microelectronic fabrication techniques allows precise control of three critical parameters, insertion depth, interface contact area, and tubing out of round. Worst case variations were found to be 5microm for insertion depth, 502microm(2) for interface contact area, and 7% for tip out of round. Histological evaluation revealed the cannula to be located correctly within the basal portion of scala tympani.

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Year:  2007        PMID: 18003542     DOI: 10.1109/IEMBS.2007.4353876

Source DB:  PubMed          Journal:  Conf Proc IEEE Eng Med Biol Soc        ISSN: 1557-170X


  6 in total

1.  Murine intracochlear drug delivery: reducing concentration gradients within the cochlea.

Authors:  David A Borkholder; Xiaoxia Zhu; Brad T Hyatt; Alfredo S Archilla; William J Livingston; Robert D Frisina
Journal:  Hear Res       Date:  2010-05-06       Impact factor: 3.208

2.  Implantable micropump technologies for murine intracochlear infusions.

Authors:  D G Johnson; M J Waldron; R D Frisina; D A Borkholder
Journal:  Annu Int Conf IEEE Eng Med Biol Soc       Date:  2010

Review 3.  Microsystems technologies for drug delivery to the inner ear.

Authors:  Erin E Leary Pararas; David A Borkholder; Jeffrey T Borenstein
Journal:  Adv Drug Deliv Rev       Date:  2012-02-21       Impact factor: 15.470

4.  In-plane biocompatible microfluidic interconnects for implantable microsystems.

Authors:  Dean G Johnson; Robert D Frisina; David A Borkholder
Journal:  IEEE Trans Biomed Eng       Date:  2010-12-10       Impact factor: 4.538

5.  Round window membrane intracochlear drug delivery enhanced by induced advection.

Authors:  David A Borkholder; Xiaoxia Zhu; Robert D Frisina
Journal:  J Control Release       Date:  2013-12-01       Impact factor: 9.776

6.  A microfluidic reciprocating intracochlear drug delivery system with reservoir and active dose control.

Authors:  Ernest S Kim; Erich Gustenhoven; Mark J Mescher; Erin E Leary Pararas; Kim A Smith; Abigail J Spencer; Vishal Tandon; Jeffrey T Borenstein; Jason Fiering
Journal:  Lab Chip       Date:  2014-02-21       Impact factor: 6.799

  6 in total

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