EEG frequency progression during induction of anesthesia: from start of infusion to onset of burst suppression pattern.

The anesthetic infusion with propofol influences EEG activity rather smoothly by changing the amplitude activity in different frequency bands. This results in a frequency progression pattern (FPP) which can be related to the depth of anesthesia. An iterative algorithm is proposed for the estimation of the shape of this pattern. The presented method is applied to the data recorded from the start of the propofol anesthetic infusion to the onset of the burst suppression pattern (BSP) with nine patients. The results reveal the underlying FPP and how the onset of the BSP is related to it. The proposed method offers potential for the development of automatic assessment systems for the depth of anesthesia.