Numerical modeling of injection flow of drug agents for controlled drug delivery.

Multiphase flow dynamics for drug delivery is significant in controlling the release of therapeutic agents at pre-determined rates to specific target sites. This paper presents the numerical investigation of injection flow of drug agents for controlled drug delivery using an improved dissipative particle dynamics (DPD) method. This DPD method employs a new conservative particle-particle interaction combining short-range repulsion and long-range attraction to simulate micro- or meso-scale multiphase flow dynamics. It is shown that the improved DPD method is capable of modeling injection flows of drug agents with different flow modes.