| Literature DB >> 18001740 |
Jeremy K Brown1, Pamela A Knight, Elisabeth M Thornton, Judith A Pate, Scott Coonrod, Hugh R P Miller, Alan D Pemberton.
Abstract
Phospholipase A2 (PLA2) enzymes play a central role in the initiation, propagation and resolution of inflammation. Here, we describe de novo expression of group IVC PLA2 (PLA2g4c) within the intestinal epithelium of Trichinella spiralis parasitised mice. This mouse mast cell protease-1 sensitive, calcium-independent PLA2 is not detectable in the jejunal epithelium of uninfected mice but becomes highly expressed within the epithelial compartment within days of nematode establishment. We propose that epithelial PLA2g4c accounts for the increased lysophospholipase activity observed during intestinal nematodiasis and that it plays a major role in the inflammatory response to nematodes.Entities:
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Year: 2007 PMID： 18001740 DOI： 10.1016/j.ijpara.2007.10.002
Source DB: PubMed Journal: Int J Parasitol ISSN： 0020-7519 Impact factor: 3.981