Literature DB >> 18001445

Prospective randomized study of oxytocin discontinuation after the active stage of labor is established.

Emin Ustunyurt1, Mustafa Ugur, Basak Ozlem Ustunyurt, Tekin Can Iskender, Ovgu Ozkan, Leyla Mollamahmutoglu.   

Abstract

AIM: To investigate the effects of discontinuing oxytocin infusion on labor outcomes once the active stage of labor is established.
METHODS: This is a prospective study involving 342 pregnant women who underwent labor induction at our institution. Patients were randomly divided into two groups. In the first group oxytocin was discontinued at the beginning of the active phase of labor, and in the other group, oxytocin was administered until delivery.
RESULTS: Duration of the active phase and the second stage of labor were longer in the oxytocin-discontinued group; however, this was not statistically significant. The rate of uterine hyperstimulation was significantly higher in oxytocin-continued group (P < 0.05). The total cesarean delivery rate for the oxytocin-continued group was 6.9%, compared with 4.8% in the oxytocin-discontinued group (P > 0.05).
CONCLUSION: Discontinuing oxytocin infusion once the active stage of labor is established may be an alternative protocol in developing countries where the conditions for fetal monitoring and emergency cesarean section are less available.

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Year:  2007        PMID: 18001445     DOI: 10.1111/j.1447-0756.2007.00659.x

Source DB:  PubMed          Journal:  J Obstet Gynaecol Res        ISSN: 1341-8076            Impact factor:   1.730


  7 in total

Review 1.  Oxytocin augmentation of labour in women with epidural analgesia for reducing operative deliveries.

Authors:  Philippa L Costley; Christine E East
Journal:  Cochrane Database Syst Rev       Date:  2013-07-11

2.  Stopping Oxytocin in Active Labor Rather Than Continuing it until Delivery: A Viable Option for the Induction of Labor.

Authors:  Seema Chopra; Sandip K SenGupta; Vanita Jain; Parveen Kumar
Journal:  Oman Med J       Date:  2015-09

Review 3.  Discontinuation of intravenous oxytocin in the active phase of induced labour.

Authors:  Sidsel Boie; Julie Glavind; Adeline V Velu; Ben Willem J Mol; Niels Uldbjerg; Irene de Graaf; Jim G Thornton; Pinar Bor; Jannet Jh Bakker
Journal:  Cochrane Database Syst Rev       Date:  2018-08-20

4.  The comparative examination of the effect of two oxytocin administration methods of labor induction on labor duration stages.

Authors:  Parvin Bahadoran; Juliana Falahati; Zahra Shahshahan; Maryam Kianpour
Journal:  Iran J Nurs Midwifery Res       Date:  2011

5.  Continued versus discontinued oxytocin after the active phase of labor: An updated systematic review and meta-analysis.

Authors:  Danni Jiang; Yang Yang; Xinxin Zhang; Xiaocui Nie
Journal:  PLoS One       Date:  2022-05-02       Impact factor: 3.752

6.  Reducing neonatal morbidity by discontinuing oxytocin during the active phase of first stage of labor: a multicenter randomized controlled trial STOPOXY.

Authors:  Aude Girault; François Goffinet; Camille Le Ray
Journal:  BMC Pregnancy Childbirth       Date:  2020-10-20       Impact factor: 3.007

Review 7.  High-dose versus low-dose oxytocin infusion regimens for induction of labour at term.

Authors:  Aaron Budden; Lily J Y Chen; Amanda Henry
Journal:  Cochrane Database Syst Rev       Date:  2014-10-09
  7 in total

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