Mother-to-child transmission of HIV: a global perspective.

HIV-1 infection is a significant global source of childhood morbidity and mortality, and mother-to-child transmission (MTCT) is the major mode of infection. Research over the past two decades has improved our understanding of the pathogenesis of MTCT and pediatric HIV-1 infection, lending to the development of effective preventive and therapeutic strategies. However, successful implementation of these strategies has been limited in resource-constrained settings, where the majority of new pediatric HIV infections now occur. Continued efforts are necessary to better understand MTCT and to refine preventive and therapeutic strategies to allow their successful implementation in the most needed places.