Literature DB >> 1799972

The intracellular distribution and activities of phosphoenolpyruvate carboxykinase isozymes in various tissues of several mammals and birds.

T J Wiese1, D O Lambeth, P D Ray.   

Abstract

1. The intracellular distribution and/or activities of phosphoenolpyruvate carboxykinase isozymes were determined in liver, kidney, gastrointestinal mucosa, adipose, skeletal muscle, brain, spleen, lung and heart of fed and fasted rabbits, guinea pigs, rats, chickens and pigeons. 2. Liver and kidney of all species contained the highest enzyme activity/g. 3. Carboxykinase activity/g gastrointestinal mucosa of rabbits was quite high compared to the low activity in guinea pig and rat mucosa and essentially undetectable activity in chicken and pigeon mucosa. 4. Activity/g was high in rat brown adipose. 5. Low carboxykinase activity/g was found in skeletal muscle of all species and in white adipose of guinea pig, rabbit and rat although activity was undetectable in white adipose of chicken and pigeon. 6. Carboxykinase activity was essentially undetectable in brain, spleen, lung and heart of all species.

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Year:  1991        PMID: 1799972     DOI: 10.1016/0305-0491(91)90378-q

Source DB:  PubMed          Journal:  Comp Biochem Physiol B        ISSN: 0305-0491


  16 in total

1.  Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism.

Authors:  P She; M Shiota; K D Shelton; R Chalkley; C Postic; M A Magnuson
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.

Authors:  Naoki Kumashiro; Derek M Erion; Dongyan Zhang; Mario Kahn; Sara A Beddow; Xin Chu; Christopher D Still; Glenn S Gerhard; Xianlin Han; James Dziura; Kitt Falk Petersen; Varman T Samuel; Gerald I Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-19       Impact factor: 11.205

Review 3.  The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked?

Authors:  Romana Stark; Richard G Kibbey
Journal:  Biochim Biophys Acta       Date:  2013-10-28

4.  Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR.

Authors:  Maha El Hage; Justine Masson; Agnès Conjard-Duplany; Bernard Ferrier; Gabriel Baverel; Guy Martin
Journal:  J Cereb Blood Flow Metab       Date:  2012-02-29       Impact factor: 6.200

Review 5.  Carboxylation and anaplerosis in neurons and glia.

Authors:  B Hassel
Journal:  Mol Neurobiol       Date:  2000 Aug-Dec       Impact factor: 5.590

6.  Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.

Authors:  Shengli Dong; Somesh Baranwal; Anapatricia Garcia; Silvia J Serrano-Gomez; Steven Eastlack; Tomoo Iwakuma; Donald Mercante; Franck Mauvais-Jarvis; Suresh K Alahari
Journal:  J Biol Chem       Date:  2017-08-24       Impact factor: 5.157

7.  Glutathione S-transferase P deficiency induces glucose intolerance via JNK-dependent enhancement of hepatic gluconeogenesis.

Authors:  Shubha Ghosh Dastidar; Ganapathy Jagatheesan; Petra Haberzettl; Jasmit Shah; Bradford G Hill; Aruni Bhatnagar; Daniel J Conklin
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-08-28       Impact factor: 4.310

8.  Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.

Authors:  Romana Stark; Francisco Pasquel; Adina Turcu; Rebecca L Pongratz; Michael Roden; Gary W Cline; Gerald I Shulman; Richard G Kibbey
Journal:  J Biol Chem       Date:  2009-07-27       Impact factor: 5.157

9.  Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons.

Authors:  Helle S Waagepetersen; Hong Qu; Leif Hertz; Ursula Sonnewald; Arne Schousboe
Journal:  Neurochem Res       Date:  2002-11       Impact factor: 3.996

10.  A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.

Authors:  Romana Stark; Fitsum Guebre-Egziabher; Xiaojian Zhao; Colleen Feriod; Jianying Dong; Tiago C Alves; Simona Ioja; Rebecca L Pongratz; Sanjay Bhanot; Michael Roden; Gary W Cline; Gerald I Shulman; Richard G Kibbey
Journal:  J Biol Chem       Date:  2014-02-04       Impact factor: 5.157

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