Literature DB >> 17998062

Analysis of hypoxia-inducible factor 1alpha expression and its effects on invasion and metastasis.

Balaji Krishnamachary1, Gregg L Semenza.   

Abstract

Hypoxia-inducible factor 1 (HIF-1) plays an important role in human cancer cell invasion and metastasis. As a result, overexpression of the HIF-1alpha subunit in biopsy specimens is associated with increased patient mortality in several common cancers, including breast adenocarcinoma and oropharyngeal squamous cell carcinoma. Here, we describe methods for immunohistochemical detection of HIF-1alpha in tumor biopsy sections and ex vivo assays for analyzing the effects of hypoxia and HIF-1 on cancer cell invasiveness and cell-cell adhesion.

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Year:  2007        PMID： 17998062     DOI： 10.1016/S0076-6879(07)35017-9

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  17 in total

1.  Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements.

Authors:  M Ariel Geer Wallace; Do-Yeon Kwon; Douglas H Weitzel; Chen-Ting Lee; Tesia N Stephenson; Jen-Tsan Chi; Robert A Mook; Mark W Dewhirst; Jiyong Hong; Michael C Fitzgerald
Journal:  J Proteome Res       Date:  2016-07-08       Impact factor: 4.466

Review 2.  Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.

Authors:  Gregg L Semenza
Journal:  Trends Pharmacol Sci       Date:  2012-03-06       Impact factor: 14.819

Review 3.  Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.

Authors:  Wen Li; Feifei Li; Xia Zhang; Hui-Kuan Lin; Chuan Xu
Journal:  Signal Transduct Target Ther       Date:  2021-12-20

4.  An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

Authors:  Yair Benita; Hirotoshi Kikuchi; Andrew D Smith; Michael Q Zhang; Daniel C Chung; Ramnik J Xavier
Journal:  Nucleic Acids Res       Date:  2009-06-02       Impact factor: 16.971

5.  Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1alpha.

Authors:  Lei Huang; Qilin Ao; Qinghua Zhang; Xiaokui Yang; Hui Xing; Fang Li; Gang Chen; Jianfeng Zhou; Shixuan Wang; Gang Xu; Li Meng; Yunping Lu; Ding Ma
Journal:  J Cancer Res Clin Oncol       Date:  2009-09-16       Impact factor: 4.553

6.  Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.

Authors:  Simona Nanni; Valentina Benvenuti; Annalisa Grasselli; Carmen Priolo; Aurora Aiello; Stefania Mattiussi; Claudia Colussi; Vittoria Lirangi; Barbara Illi; Manuela D'Eletto; Anna Maria Cianciulli; Michele Gallucci; Piero De Carli; Steno Sentinelli; Marcella Mottolese; Paolo Carlini; Lidia Strigari; Stephen Finn; Elke Mueller; Giorgio Arcangeli; Carlo Gaetano; Maurizio C Capogrossi; Raffaele Perrone Donnorso; Silvia Bacchetti; Ada Sacchi; Alfredo Pontecorvi; Massimo Loda; Antonella Farsetti
Journal:  J Clin Invest       Date:  2009-04-13       Impact factor: 14.808

7.  Benzimidazole analogs as potent hypoxia inducible factor inhibitors: synthesis, biological evaluation, and profiling drug-like properties.

Authors:  Jianjun Chen; Jin Wang; Luciana P Schwab; Kyung-Tae Park; Tiffany N Seagroves; Lisa K Jennings; Duane D Miller; Wei Li
Journal:  Anticancer Res       Date:  2014-08       Impact factor: 2.480

8.  Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.

Authors:  Lisha Xiang; Daniele M Gilkes; Pallavi Chaturvedi; Weibo Luo; Hongxia Hu; Naoharu Takano; Houjie Liang; Gregg L Semenza
Journal:  J Mol Med (Berl)       Date:  2013-11-20       Impact factor: 4.599

9.  Fabrication of PNIPAm-based thermoresponsive hydrogel microwell arrays for tumor spheroid formation.

Authors:  Dinesh Dhamecha; Duong Le; Tomali Chakravarty; Kalindu Perera; Arnob Dutta; Jyothi U Menon
Journal:  Mater Sci Eng C Mater Biol Appl       Date:  2021-04-14

10.  Collagen prolyl hydroxylases are essential for breast cancer metastasis.

Authors:  Daniele M Gilkes; Pallavi Chaturvedi; Saumendra Bajpai; Carmen C Wong; Hong Wei; Stephen Pitcairn; Maimon E Hubbi; Denis Wirtz; Gregg L Semenza
Journal:  Cancer Res       Date:  2013-03-28       Impact factor: 12.701
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