OBJECTIVE: Research in animals has shown that exposure to stressors during pregnancy is associated with offspring behavioural disorders. We aimed to study the effect of in utero exposure to the Chernobyl disaster in 1986, and maternal anxiety presumably associated with that exposure, on behaviour disorder observed at age 14. METHOD: Exposed (n = 232) and non-exposed Finnish twins (n = 572) were compared. A semi-structured interview was used to assess lifetime symptoms of depression, generalized anxiety disorder, attention deficit hyperactivity disorder, conduct disorder and oppositional defiant disorder symptoms. RESULTS: Adolescents who were exposed from the second trimester in pregnancy onwards, had a 2.32-fold risk (95% CI: 1.13-4.72) of having lifetime depression symptoms, an increased risk of fulfilling DSM-III-R criteria of a major depressive disorder (OR = 2.48, 95% CI: 1.06-5.7), and a 2.01-fold risk (95% CI: 1.14-3.52) of having attention deficit hyperactivity disorder symptoms. CONCLUSION: Perturbations in fetal brain development during the second trimester may be associated with the increased prevalence of depressive and attention deficit hyperactivity disorder symptoms.
OBJECTIVE: Research in animals has shown that exposure to stressors during pregnancy is associated with offspring behavioural disorders. We aimed to study the effect of in utero exposure to the Chernobyl disaster in 1986, and maternal anxiety presumably associated with that exposure, on behaviour disorder observed at age 14. METHOD: Exposed (n = 232) and non-exposed Finnish twins (n = 572) were compared. A semi-structured interview was used to assess lifetime symptoms of depression, generalized anxiety disorder, attention deficit hyperactivity disorder, conduct disorder and oppositional defiant disorder symptoms. RESULTS: Adolescents who were exposed from the second trimester in pregnancy onwards, had a 2.32-fold risk (95% CI: 1.13-4.72) of having lifetime depression symptoms, an increased risk of fulfilling DSM-III-R criteria of a major depressive disorder (OR = 2.48, 95% CI: 1.06-5.7), and a 2.01-fold risk (95% CI: 1.14-3.52) of having attention deficit hyperactivity disorder symptoms. CONCLUSION: Perturbations in fetal brain development during the second trimester may be associated with the increased prevalence of depressive and attention deficit hyperactivity disorder symptoms.
Authors: S Kuperman; S S Schlosser; J R Kramer; K Bucholz; V Hesselbrock; T Reich; W Reich Journal: Am J Psychiatry Date: 2001-12 Impact factor: 18.112
Authors: Thomas G O'Connor; Jonathan Heron; Jean Golding; Michael Beveridge; Vivette Glover Journal: Br J Psychiatry Date: 2002-06 Impact factor: 9.319
Authors: Barbara M Gutteling; Carolina de Weerth; Sophie H N Willemsen-Swinkels; Anja C Huizink; Eduard J H Mulder; Gerard H A Visser; Jan K Buitelaar Journal: Eur Child Adolesc Psychiatry Date: 2005-02 Impact factor: 4.785
Authors: Anja C Huizink; Pascale G Robles de Medina; Eduard J H Mulder; Gerard H A Visser; Jan K Buitelaar Journal: J Am Acad Child Adolesc Psychiatry Date: 2002-09 Impact factor: 8.829
Authors: A Auvinen; M Vahteristo; H Arvela; M Suomela; T Rahola; M Hakama; T Rytömaa Journal: Environ Health Perspect Date: 2001-02 Impact factor: 9.031
Authors: Alytia A Levendosky; G Anne Bogat; Joseph S Lonstein; Cecilia Martinez-Torteya; Maria Muzik; Douglas A Granger; Alexander von Eye Journal: Stress Date: 2015-12-02 Impact factor: 3.493
Authors: Evelyn J Bromet; Lin T Guey; David P Taormina; Gabrielle A Carlson; Johan M Havenaar; Roman Kotov; Semyon F Gluzman Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2010-03-11 Impact factor: 4.328
Authors: Claudia Buss; Elysia Poggi Davis; Babak Shahbaba; Jens C Pruessner; Kevin Head; Curt A Sandman Journal: Proc Natl Acad Sci U S A Date: 2012-04-23 Impact factor: 11.205
Authors: Sarah Lederberg Stone; Hafsatou Diop; Eugene Declercq; Howard J Cabral; Matthew P Fox; Lauren A Wise Journal: J Womens Health (Larchmt) Date: 2015-03-09 Impact factor: 2.681