Literature DB >> 17997491

Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts.

Kimberly M Winges1, Donald H Gilden, Jeffrey L Bennett, Xiaoli Yu, Alanna M Ritchie, Gregory P Owens.   

Abstract

Fluorescence-activated cell sorting (FACS) analysis of B cell subtypes in 17 CSF samples from 15 patients with clinically-definite MS revealed that CD19+ B cells accounted for 2 to 11% (mean 5%) and CD138+ cells constituted 0 to 5% (mean 2%) of total CSF lymphocytes. Further stratification of CD138+ cells based on expression levels of CD19 showed that CD138+19+ plasma blasts constituted 89+/-2% (mean+/-SE) of the CD138+ cell population (P<0.00001), with more mature plasma cells (CD138+19-) constituting the remaining 11+/-2%. Sequence analysis of immunoglobulin variable regions in single CD138+19+ and CD138+19- cells sorted from MS CSF identified many of the same clonal populations in both populations, indicating a continuum of clonally related plasma cell subtypes of which CD138+19+ plasma blasts are most abundant.

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Year:  2007        PMID： 17997491     DOI： 10.1016/j.jneuroim.2007.10.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  19 in total

Review 1.  Viruses and multiple sclerosis.

Authors:  Gregory P Owens; Don Gilden; Mark P Burgoon; Xiaoli Yu; Jeffrey L Bennett
Journal:  Neuroscientist       Date:  2011-12       Impact factor: 7.519

2.  Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients.

Authors:  Jacqueline R Rivas; Sara J Ireland; Rati Chkheidze; William H Rounds; Joseph Lim; Jordan Johnson; Denise M O Ramirez; Ann J Ligocki; Ding Chen; Alyssa A Guzman; Mark Woodhall; Patrick C Wilson; Eric Meffre; Charles White; Benjamin M Greenberg; Patrick Waters; Lindsay G Cowell; Ann M Stowe; Nancy L Monson
Journal:  Acta Neuropathol       Date:  2016-10-11       Impact factor: 17.088

3.  Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants.

Authors:  Kevin Blauth; John Soltys; Adeline Matschulat; Cory R Reiter; Alanna Ritchie; Nicholas L Baird; Jeffrey L Bennett; Gregory P Owens
Journal:  Acta Neuropathol       Date:  2015-10-28       Impact factor: 17.088

Review 4.  B cells in multiple sclerosis: connecting the dots.

Authors:  H-Christian von Büdingen; Amit Bar-Or; Scott S Zamvil
Journal:  Curr Opin Immunol       Date:  2011-10-07       Impact factor: 7.486

5.  Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients.

Authors:  Erica L Eggers; Brady A Michel; Hao Wu; Sheng-Zhi Wang; Carolyn J Bevan; Aya Abounasr; Natalie S Pierson; Antje Bischof; Max Kazer; Elizabeth Leitner; Ariele L Greenfield; Stanislas Demuth; Michael R Wilson; Roland G Henry; Bruce Ac Cree; Stephen L Hauser; H-Christian von Büdingen
Journal:  JCI Insight       Date:  2017-11-16

6.  Peptide reactivity between multiple sclerosis (MS) CSF IgG and recombinant antibodies generated from clonally expanded plasma cells in MS CSF.

Authors:  Xiaoli Yu; Don Gilden; Laura Schambers; Olga Barmina; Mark Burgoon; Jeffrey Bennett; Greg Owens
Journal:  J Neuroimmunol       Date:  2010-12-21       Impact factor: 3.478

7.  A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.

Authors:  Krishnakumar N Menon; David L Steer; Martin Short; Steven Petratos; Ian Smith; Claude C A Bernard
Journal:  Mol Cell Proteomics       Date:  2011-03-18       Impact factor: 5.911

8.  Ex vivo characterization and isolation of rare memory B cells with antigen tetramers.

Authors:  Bettina Franz; Kenneth F May; Glenn Dranoff; Kai Wucherpfennig
Journal:  Blood       Date:  2011-05-06       Impact factor: 22.113

9.  Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis.

Authors:  S A Sargsyan; A J Shearer; A M Ritchie; M P Burgoon; S Anderson; B Hemmer; C Stadelmann; S Gattenlöhner; G P Owens; D Gilden; J L Bennett
Journal:  Neurology       Date:  2010-03-10       Impact factor: 9.910

10.  Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica.

Authors:  Jeffrey L Bennett; Chiwah Lam; Sudhakar Reddy Kalluri; Philippe Saikali; Katherine Bautista; Cecily Dupree; Magdalena Glogowska; David Case; Jack P Antel; Gregory P Owens; Don Gilden; Stefan Nessler; Christine Stadelmann; Bernhard Hemmer
Journal:  Ann Neurol       Date:  2009-11       Impact factor: 10.422
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