Literature DB >> 17997168

Genome-wide association scans for Type 2 diabetes: new insights into biology and therapy.

Mark I McCarthy1, Eleftheria Zeggini.   

Abstract

Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 diabetes has proven a challenging task, rewarded, until recently, with only limited success. However, the field of Type 2 diabetes genetics has been transformed over the past few months, with the publication of six genome-wide association scans, leading to the establishment of novel genomic regions that harbour disease susceptibility loci. Here, we provide an overview of the main recent findings and discuss their significance in providing biological insights and their translational implications.

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Year:  2007        PMID： 17997168     DOI： 10.1016/j.tips.2007.10.008

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  11 in total

Review 1.  Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.

Authors:  Evanthia Diamanti-Kandarakis; Andrea Dunaif
Journal:  Endocr Rev       Date:  2012-10-12       Impact factor: 19.871

2.  A map of open chromatin in human pancreatic islets.

Authors:  Kyle J Gaulton; Takao Nammo; Lorenzo Pasquali; Jeremy M Simon; Paul G Giresi; Marie P Fogarty; Tami M Panhuis; Piotr Mieczkowski; Antonio Secchi; Domenico Bosco; Thierry Berney; Eduard Montanya; Karen L Mohlke; Jason D Lieb; Jorge Ferrer
Journal:  Nat Genet       Date:  2010-01-31       Impact factor: 38.330

3.  Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng.

Authors:  Yun Wang; Patsy M Nishina; Jürgen K Naggert
Journal:  J Endocrinol       Date:  2009-07-08       Impact factor: 4.286

4.  Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.

Authors:  Alka Malhotra; Robert P Igo; Farook Thameem; W H Linda Kao; Hanna E Abboud; Sharon G Adler; Nedal H Arar; Donald W Bowden; Ravindranath Duggirala; Barry I Freedman; Katrina A B Goddard; Eli Ipp; Sudha K Iyengar; Paul L Kimmel; William C Knowler; Orly Kohn; David Leehey; Lucy A Meoni; Robert G Nelson; Susanne B Nicholas; Rulan S Parekh; Stephen S Rich; Yii-Der I Chen; Mohammed F Saad; Marina Scavini; Jeffrey R Schelling; John R Sedor; Vallabh O Shah; Kent D Taylor; Denyse Thornley-Brown; Philip G Zager; Amanda Horvath; Robert L Hanson
Journal:  Diabetes Metab Res Rev       Date:  2009-11       Impact factor: 4.876

5.  Resting heart rate as a marker for identifying the risk of undiagnosed type 2 diabetes mellitus: a cross-sectional survey.

Authors:  Yu-qian Li; Chang-qing Sun; Lin-lin Li; Ling Wang; Yi-rui Guo; Ai-guo You; Yuan-lin Xi; Chong-jian Wang
Journal:  BMC Public Health       Date:  2014-10-09       Impact factor: 3.295

6.  Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Authors:  Eleftheria Zeggini; Laura J Scott; Richa Saxena; Benjamin F Voight; Jonathan L Marchini; Tianle Hu; Paul I W de Bakker; Gonçalo R Abecasis; Peter Almgren; Gitte Andersen; Kristin Ardlie; Kristina Bengtsson Boström; Richard N Bergman; Lori L Bonnycastle; Knut Borch-Johnsen; Noël P Burtt; Hong Chen; Peter S Chines; Mark J Daly; Parimal Deodhar; Chia-Jen Ding; Alex S F Doney; William L Duren; Katherine S Elliott; Michael R Erdos; Timothy M Frayling; Rachel M Freathy; Lauren Gianniny; Harald Grallert; Niels Grarup; Christopher J Groves; Candace Guiducci; Torben Hansen; Christian Herder; Graham A Hitman; Thomas E Hughes; Bo Isomaa; Anne U Jackson; Torben Jørgensen; Augustine Kong; Kari Kubalanza; Finny G Kuruvilla; Johanna Kuusisto; Claudia Langenberg; Hana Lango; Torsten Lauritzen; Yun Li; Cecilia M Lindgren; Valeriya Lyssenko; Amanda F Marvelle; Christa Meisinger; Kristian Midthjell; Karen L Mohlke; Mario A Morken; Andrew D Morris; Narisu Narisu; Peter Nilsson; Katharine R Owen; Colin N A Palmer; Felicity Payne; John R B Perry; Elin Pettersen; Carl Platou; Inga Prokopenko; Lu Qi; Li Qin; Nigel W Rayner; Matthew Rees; Jeffrey J Roix; Anelli Sandbaek; Beverley Shields; Marketa Sjögren; Valgerdur Steinthorsdottir; Heather M Stringham; Amy J Swift; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Nicholas J Timpson; Tiinamaija Tuomi; Jaakko Tuomilehto; Mark Walker; Richard M Watanabe; Michael N Weedon; Cristen J Willer; Thomas Illig; Kristian Hveem; Frank B Hu; Markku Laakso; Kari Stefansson; Oluf Pedersen; Nicholas J Wareham; Inês Barroso; Andrew T Hattersley; Francis S Collins; Leif Groop; Mark I McCarthy; Michael Boehnke; David Altshuler
Journal:  Nat Genet       Date:  2008-03-30       Impact factor: 38.330

7.  Pharmacogenomics in type II diabetes mellitus management: Steps toward personalized medicine.

Authors:  Peter Avery; Shaymaa S Mousa; Shaker A Mousa
Journal:  Pharmgenomics Pers Med       Date:  2009-09-13

8.  Genes associated with risk of type 2 diabetes identified by a candidate-wide association scan: as a trickle becomes a flood.

Authors:  Stephen S Rich; Jill M Norris; Jerome I Rotter
Journal:  Diabetes       Date:  2008-11       Impact factor: 9.461

9.  Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits.

Authors:  Camilla Noelle Rathcke; Johan Holmkvist; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Borbye Pedersen; Henrik Vestergaard
Journal:  PLoS One       Date:  2009-05-07       Impact factor: 3.240

10.  Why treatment fails in type 2 diabetes.

Authors:  Anders Rosengren; Xingjun Jing; Lena Eliasson; Erik Renström
Journal:  PLoS Med       Date:  2008-10-28       Impact factor: 11.069
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